Features of the drug Nimefast - detailed instructions for use

Features and characteristics

The active ingredient of the drug is nimesulide 100 mg. Belongs to non-steroidal anti-inflammatory drugs.

The main effect is to reduce temperature, relieve inflammation, eliminate pain, which is achieved by suppressing the formation of free radicals and the production of prostanoids.

The drug is well absorbed, the maximum accumulation in the inflamed area is 46%, in the joint fluid 42%. The substance is eliminated through the kidneys and liver.

Indications for use of Nymefast tablets

Let's determine what Nymefast tablets help with:

1. Pathologies of the musculoskeletal system, accompanied by pain and inflammation during degenerative-dystrophic changes. These are all types of arthritis, tendinitis, bursitis, myositis, etc.;
2. Toothache and headache;
3. Injuries and wounds;
4. Myalgia, neuralgia, arthralgia;
5. Algodysmenorrhea (pain during menstruation, which worsens general well-being);
6. Reducing temperature during febrile conditions, acute respiratory viral infections and influenza.

Nymefast took three tablets, what should I do?

With long-term use it does not accumulate. Nimesulide is extensively metabolized in the liver by various routes, including cytochrome P450 (CYP) 2C9 isoenzymes. Therefore, there is a potential for drug interactions when coadministering drugs that are metabolized by CYP2C9. Indications for use

• Treatment of acute pain associated with injuries of the musculoskeletal system, injuries and wounds of soft tissues, inflammatory diseases of the musculoskeletal system (arthritis, bursitis, myositis).
• Symptomatic treatment of pain due to osteoarthritis.
• Primary dysmenorrhea.

The decision to prescribe Nymefast should be based on an assessment of the patient's individual risk factors.

httpv://www.youtube.com/watch?v=embed/xcAfXhSJQMg

^ Method of administration and dosage Take orally after meals.

And the only way to avoid this is to remove or maintain the tooth in normal condition - this is Nimesulide, or Nimegesik, or Nimefast. I like Nymefast the most, since it is almost tasteless, you can take it by simply chewing the tablet until completely dissolved, or dissolve it in a glass of water, fifty or one hundred grams. The tablet dissolves perfectly in water, turning it yellowish.

The liquid medicine has absolutely no taste and is easy to drink. Relief comes very quickly and the inflammation goes away. I take this medicine for no more than five days, or even less. I have to do this every six months, or 8 months, or remove the tooth, I prefer to delay the removal.

There are contraindications, so a visit to the doctor is a must. For dental pain, I will definitely recommend this medicine. It helps great. Be healthy and try not to get sick. NIMEFAST Name of the drug: Trade name: Nimefast International nonproprietary name: Nimesulide General characteristics: Nimesulide, 100 mg. The tablets are almost white with a yellowish tint, round, biconvex, with a smooth surface. Composition of the medicinal product: Each tablet contains the active ingredient: Nimesulide 100 mg; excipients: microcrystalline cellulose, sodium starch glycolate (type A), magnesium stearate, povidone, lactose. ^ Dosage form: tablets. ATX code: M01AX17. Pharmacotherapeutic group Other non-steroidal anti-inflammatory and antirheumatic drugs. Nimesulide. ^ Pharmacological properties Pharmacodynamics Nimefast is a non-steroidal anti-inflammatory drug (NSAID) from the sulfonanilide class. Has anti-inflammatory, analgesic and antipyretic effects.

What are the contraindications?

• Individual sensitivity to the drug or other non-steroidal drugs, including aspirin;
• Erosion and ulcer of the stomach and duodenum in the acute period;
• History of gastric bleeding;
• Bleeding disorders;
• Pathologies of the kidneys and liver;
• Pregnancy and breastfeeding period;
• Children under 12 years old;
• Enterocolitis;
• Cirrhosis of the liver;
• Alcohol and drug addictions;
• Blood coagulation pathologies;
• Heart defects and heart failure;
• This drug should not be prescribed concomitantly with other non-steroidal anti-inflammatory drugs.

The drug is prescribed with caution for high blood pressure and type II diabetes mellitus.

Nimefast 100mg tablets instructions for use

History of gastrointestinal tract; ■ history of cerebrovascular hemorrhages; ■ severe blood coagulation disorders (pathology of the components of the hemostasis system, for example: coagulopathy, thrombocytopathy, vasopathy, combined hemostasiopathy); ■ severe renal failure (creatinine clearance less than 30 ml/min); ■ severe heart failure; ■ liver dysfunction, liver failure; ■ alcoholism, drug dependence; ■ history of hepatotoxic reactions to nimesulide, simultaneous administration with other hepatotoxic drugs; ■ increased body temperature and/or flu-like symptoms Pregnancy and lactation Not recommended for use during pregnancy.

Nimefast: instructions for use and dosage regimen

The drug is taken orally. To reduce the likelihood of side effects, it is necessary to take the tablets after meals and in the minimum effective dosage.

Before taking, the tablet must be dissolved in water (50-100ml) or chewed completely. The prepared solution cannot be stored.

For adults, the dosage of the drug per day is 100 mg twice a day. Children 12-18 years old – 100 mg per day; if the child’s weight exceeds 40 kg, then the daily dose can be increased by 100 mg.

Instructions for use of Nimefast determine the duration of taking the drug - no more than two weeks.

Patients with renal failure (creatinine clearance from 30 to 80 ml/min) and the elderly do not need to reduce the dosage.

What side effects may occur when taking Nymefast?

• CNS. Dizziness, headache, drowsiness or insomnia, anxiety and depression;
• Organs of vision. Decreased visual acuity;
• Respiratory system. Shortness of breath, bronchospasm;
• Gastrointestinal tract. Dyspeptic disorders (heartburn, nausea, vomiting), stool disorders (diarrhea, constipation), epigastric pain, ulcerative lesions of the gastric mucosa, oral cavity and duodenum, gastric bleeding, liver dysfunction, congestion in the gallbladder, acute hepatitis ;
• Circulatory system. Anemia (decreased hemoglobin level), thrombocytopenia (decreased platelet count), leukopenia (decrease in white blood cell count), increased liver tests (ALT and AST);
• Metabolism. Increased potassium;
• Urinary system. Swelling of tissues and organs, fluid retention, decreased amount of urine excreted, nephritis;
• Heart and blood vessels. Rhythm disturbances, rapid heartbeat, increased blood pressure;
• Allergic manifestations. Rash, dermatitis, erythema, urticaria, rarely - anaphylactic shock and angioedema.

Nymefast tablets 100 mg packaging No. 20

Nimefast Trade name: Nimefast International nonproprietary name: Nimesulide General characteristics: Nimesulide, 100 mg. Light yellow, round, biconvex tablets. Composition of the drug: Each tablet contains the active ingredient: nimesulide 100 mg; excipients: microcrystalline cellulose, sodium starch glycolate (type A), magnesium stearate, povidone, lactose. Dosage form: tablets. ATC code: MO 1 AX 17. Pharmacotherapeutic group Other nonsteroidal anti-inflammatory and antirheumatic drugs. Nimesulide.

Pharmacological properties Pharmacodynamics Nimefast is a non-steroidal anti-inflammatory drug (NSAID) from the sulfonanilide class. Has anti-inflammatory, analgesic and antipyretic effects. Nymefast belongs to a new generation of NSAIDs, the mechanism of action of which is associated with selective inhibition of cyclooxygenase-2. Pharmacokinetics When taken orally, the drug is well absorbed from the gastrointestinal tract. The maximum concentration of the active substance in the blood plasma is achieved 2-3 hours after taking the drug. Taking the drug simultaneously with food slows down the rate of absorption, but does not affect the degree of absorption. Plasma protein binding is 97.5%. The volume of distribution is 0.19 - 0.35 l/kg. Nimesulide is actively metabolized in the liver with the formation of several metabolites, excreted mainly in urine (50%) and feces (29%). The main metabolite is the pharmacologically active hydroxynimesulide (25%). The half-life from plasma is 3.2 - 6 hours. In patients with renal failure (creatinine clearance 1.8 - 4.8 l/h or 30 - 80 ml/min), as well as in children and the elderly, the pharmacokinetic profile of nimesulide did not change significantly. With long-term use it does not accumulate. Nimesulide is extensively metabolized in the liver by various routes, including cytochrome P450 (CYP) 2C9 isoenzymes. Therefore, there is a potential for drug interactions when coadministering drugs that are metabolized by CYP2C9.

Indications for use Treatment of acute pain; Primary dysmenorrhea. Nimesulide can only be prescribed as a second-line treatment. The decision to prescribe nimesulide should be based on an overall risk assessment for each patient.

Directions for use and dosage: Take orally after meals. Before use, the tablet should be dissolved in 50-100 ml of water or chewed until completely dissolved in the mouth. The prepared solution cannot be stored. The usual dose of Nymefast for adults is 100 mg twice a day. For children aged 12 to 18 years, the daily dose is 100 mg, and for those with a body weight over 40 kg - 100 mg 2 times a day. In order to reduce the frequency of side effects, the drug should be prescribed in a minimum therapeutic dose. The maximum duration of taking Nymefast should not exceed 15 days. In patients with renal failure with a creatinine clearance of 30-80 ml/min, as well as in old age, a dose reduction of Nimefast is not required.

Side effects Cases of adverse reactions are classified as very common (> 1/10), common (> 1/100, <1/10), uncommon (> 1/1,000 to <1/100), rare (> 1/10,000, < 1/1000), very rare (<1/10,000), including isolated reports. From the hematopoietic and lymphatic system: Rarely, anemia, eosinophilia; Very rarely thrombocytopenia, pancytopenic purpura. From the immune system: Rarely hypersensitivity; Very rare: anaphylaxis. Metabolism and nutrition: Rarely, hyperkalemia. From the psyche: rarely anxiety, nervousness, nightmares; From the central nervous system: infrequently dizziness. Very rarely, headache, somnolence, encephalopathy (Reye's syndrome). From the organs of vision: Rarely blurred vision; Very rarely, visual impairment. On the part of the hearing and vestibular apparatus: Very rarely, dizziness. Cardiac disorders: Rarely, tachycardia; Uncommon: hypertension. From the cardiovascular system: Rarely hemorrhages, fluctuations in blood pressure, hot flashes, From the respiratory system, chest and mediastinum: Uncommon - shortness of breath Very rarely - bronchospasm, asthma attack. From the gastrointestinal tract: Often diarrhea, nausea, vomiting, constipation, flatulence, gastritis; Uncommon: gastrointestinal bleeding, ulcer and perforation, duodenal ulcer, ulcer and perforation of gastric ulcer; Very rarely: abdominal pain, dyspepsia, stomatitis, melena. From the hepato-biliary system: Often increased levels of liver enzymes; Very rarely, hepatitis, fulminant hepatitis (including deaths), cholestatic jaundice; Uncommon: itching, irritation, increased sweating. From the skin and subcutaneous tissue: Rarely, erythema, dermatitis; Very rarely: urticaria, angioedema, facial edema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis. From the kidneys and urinary tract: Rarely, dysuria, hematuria, urinary retention; Very rarely, renal failure, oliguria, interstitial nephritis. General disorders: Rarely, malaise, asthenia; Very rarely hypothermia.

Contraindications: hypersensitivity to nimesulide and other components of the drug; hypersensitivity to acetylsalicylic acid and other NSAIDs (including a history), including such manifestations as bronchial asthma, urticaria or rhinitis; erosive and ulcerative lesions of the stomach and duodenum in the acute phase; history of gastrointestinal bleeding; history of cerebrovascular hemorrhages; severe blood coagulation disorders (pathology of the components of the hemostasis system, for example: oagulopathy, thrombocytopathy, vasopathy, combined hemostasiopathy); severe renal failure (creatinine clearance less than 30 ml/min); severe heart failure; liver dysfunction, liver failure; alcoholism, drug addiction; history of hepatotoxic reactions to nimesulide, simultaneous administration with other hepatotoxic drugs; fever and/or flu-like symptoms; pregnancy and breastfeeding; children up to 12 years of age.

Overdose When taking Nymefast in a dose significantly higher than the recommended one, you can expect overdose symptoms characteristic of NSAIDs: dizziness, nausea, vomiting, epigastric pain, which are usually reversible with maintenance treatment. Gastrointestinal bleeding is possible. Hypertension and acute renal failure occur rarely. Anaphylactic reactions may develop. Treatment: symptomatic and supportive; there are no specific antidotes. Hemodialysis, as well as forced diuresis, urine oxidation or hemoperfusion may be ineffective due to the high degree (up to 97.5%) of nimesulide binding to blood proteins. Vomiting can be induced, activated carbon (60-100 g) and an osmotic laxative are introduced into the stomach during the first 4 hours after an overdose. It is necessary to monitor liver and kidney functions.

Precautions The drug should be prescribed with caution for arterial hypertension, heart failure, and type 2 diabetes mellitus.

Use during pregnancy Not recommended for use during pregnancy. The use of nimesulide may impair female fertility and is not recommended for women planning pregnancy, having difficulty becoming pregnant, or undergoing examination for infertility. Like other NSAIDs that are known to inhibit prostaglandin synthesis, nimesulide can cause premature closure of the ductus arteriosus, pulmonary hypertension, oliguria, oligoamnion, increased risk of bleeding, weakness of labor and the development of peripheral edema. There have been isolated cases of renal failure in children of women who took Nymefast in late pregnancy.

Use during lactation Passes into breast milk, therefore, its use during lactation is not recommended.

Use in the Elderly Elderly patients are particularly susceptible to the side effects of NSAIDs, including gastrointestinal bleeding, renal, cardiac and hepatic dysfunction. Therefore, adequate clinical monitoring is recommended.

Special instructions The risk of side effects after using Nimefast can be reduced if treatment is carried out in a short course and the drug is discontinued upon achieving a therapeutic effect or due to ineffectiveness. Patients who experience deterioration in liver function during the use of Nymefast (for example, anorexia, nausea, vomiting, abdominal pain, weakness, dark urine) or who experience abnormal liver function tests should discontinue use of the drug. Such patients should not be re-prescribed Nymefast. There are known cases of liver damage even after short-term use of the drug. The combined use of different NSAIDs is not recommended. It is recommended to avoid the combined use of Nymefast with other painkillers. Patients who experience an increase in body temperature or develop flu-like symptoms while using Nymefast should stop taking the drug. During treatment, ulceration or gastrointestinal bleeding is also possible, with or without previous symptoms, both with and without a history of gastrointestinal disorders. In patients with impaired renal or cardiac function, caution should be exercised as Nymefast may cause deterioration of renal function. If the condition worsens, the drug should be discontinued. Nimefast should be used with caution in patients taking drugs that reduce blood clotting or inhibit platelet aggregation. However, Nymefast is not a replacement for acetylsalicylic acid for cardiovascular prevention. Nymefast contains lactose and is therefore not recommended for patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption syndrome. It is recommended to avoid the combined use of Nymefast with alcoholic beverages.

Effect on the ability to drive vehicles and operate machinery Patients who experience dizziness or drowsiness should refrain from driving a car or working with mechanisms that require increased concentration and precise coordination of movements when using Nymefast.

Interaction with other drugs Pharmacodynamic interaction Warfarin and similar anticoagulants, acetylsalicylic acid: increased risk of bleeding, therefore simultaneous use with Nimefast is not recommended, and is contraindicated in patients with severe bleeding disorders. If the use of such a combination is necessary, monitoring the effect of anticoagulants is required. Pharmacodynamic/pharmacokinetic interaction with diuretics Furosemide: in healthy individuals, nimesulide transiently reduces the excretion of sodium and, to a lesser extent, potassium and reduces the diuretic effect of furosemide. The simultaneous use of nimesulide and furosemide leads to a decrease (by approximately 20%) in the AUC and total excretion of furosemide, without changing its renal clearance. The simultaneous use of nimesulide and furosemide requires caution in patients with impaired renal and cardiac function. Pharmacokinetic interactions with other drugs Lithium preparations: there is evidence that NSAIDs reduce the clearance of lithium, which leads to an increase in the concentration of lithium in the blood plasma and an increase in its toxicity. Therefore, when using nimesulide and lithium preparations simultaneously, it is necessary to regularly monitor the concentration of lithium in the blood plasma. The interaction of nimesulide with glibenclamide, theophylline, warfarin, digoxin, cimetidine and antacids (combinations of aluminum and magnesium compounds) has been studied in vivo. No clinically significant interactions were identified. Nimesulide inhibits the enzyme CYP 2C9, therefore, the concentration in the blood plasma of drugs metabolized with the participation of this enzyme, when used simultaneously with Methotrexate: an increase in the concentration of methotrexate in the blood serum and, therefore, its toxicity, caution must be exercised if nimesulide is used less than a day before or after using methotrexate. Cyclosporine: the nephrotoxicity of cyclosporine may increase when used simultaneously with nimesulide.

Influence of other drugs on the pharmacological profile of nimesulide In vitro studies have demonstrated that tolbutamide, salicylic and valproic acid displace nimesulide from protein binding sites. However, despite the possible increase in plasma concentrations of nimesulide, this interaction is not clinically significant.

Conditions and shelf life Store in a place protected from moisture and light, at a temperature not exceeding 25 C. Keep out of the reach of children. Shelf life: 2 years. Do not use after the expiration date stated on the packaging.

Conditions of release By prescription.

Packaging of 10 tablets in a blister pack made of polyvinyl chloride film and aluminum foil. Two or three blister packs along with instructions for use in a pack.

Manufacturer Rubicon LLC, RB, 210002, Vitebsk, MGorkogo str., 62B, fax: +375, e-mail: [email protected]

special instructions

Nymefast is not recommended for women who are trying to get pregnant, as the drug reduces fertility. As a result of the fact that the active substance - nimesulide - suppresses the connection of prostanoids, pulmonary hypertension, premature closure of the ductus arteriosus, oliguria, the likelihood of bleeding, weak labor, and edema may develop.

The development of renal failure occurred in the children of those women who took this anti-inflammatory drug in the last stages of pregnancy.

Elderly patients are much more likely to be affected by side effects from taking anti-inflammatory drugs, so Nymefast to this group of patients should be prescribed in minimal doses and under strict monitoring of blood counts, kidney function, liver and heart function.

The likelihood of side effects can also be reduced by discontinuing the drug when a positive effect from treatment is achieved.

You cannot use Nymefast and other painkillers, even from a different pharmacological group, as the likelihood of stroke, heart attack and thrombopulmonary embolism increases.

Medicine knows cases of significant liver damage even as a result of short-term use of the drug, so patients who experienced deterioration in liver parameters on Nymefast, nausea, vomiting, dark urine, severe abdominal pain, must urgently discontinue the drug and never prescribe it again.

If a person’s body temperature rises during therapy with this drug, it is also necessary to interrupt treatment.

Nymefast should be taken with extreme caution in people undergoing anticoagulant therapy.

The drug contains lactose and is therefore not recommended for persons with genetic galactose intolerance.

You should not drink alcoholic beverages during anti-inflammatory drug therapy.

Nymefast took three tablets, what should I do?

Use in the Elderly Elderly patients are particularly susceptible to the side effects of NSAIDs, including gastrointestinal bleeding, renal, cardiac and hepatic dysfunction. Therefore, adequate clinical monitoring is recommended. ^ Special instructions The risk of side effects after using nimesulide can be reduced if treatment is carried out in a short course and the drug is discontinued upon achieving a therapeutic effect or due to ineffectiveness. Patients who experience deterioration in liver function during use of nimesulide (for example, anorexia, nausea, vomiting, abdominal pain, weakness, dark urine) or who experience abnormal liver function tests should discontinue use of the drug.

Such patients should not be re-prescribed nimesulide. There are known cases of liver damage even after short-term use of the drug.

However, nimesulide is not a replacement for acetylsalicylic acid for cardiovascular prevention. Nymefast contains lactose and is therefore not recommended for patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption syndrome.

It is recommended to avoid the combined use of Nymefast with alcoholic beverages. Effect on the ability to drive vehicles and operate machinery Patients who experience dizziness or drowsiness should refrain from driving a car or operating mechanisms that require increased concentration and precise coordination of movements when using Nimesulide-Rn.

Interaction with other drugs Pharmacodynamic interaction. Nymefast belongs to a new generation of NSAIDs, the mechanism of action of which is associated with selective inhibition of cyclooxygenase-2. Pharmacokinetics When taken orally, the drug is well absorbed from the gastrointestinal tract. The maximum concentration of the active substance in the blood plasma is achieved 2-3 hours after taking the drug. Taking the drug simultaneously with food slows down the rate of absorption, but does not affect the degree of absorption. Plasma protein binding is 97.5%. The volume of distribution is 0.19 – 0.35 l/kg. Nimesulide is actively metabolized in the liver with the formation of several metabolites, excreted mainly in urine (50%) and feces (29%). The main metabolite is the pharmacologically active hydroxynimesulide (25%). The half-life from plasma is 3.2 – 6 hours.

How Nymefast interacts with other drugs

The simultaneous use of an anti-inflammatory drug and aspirin should not be allowed, as the likelihood of bleeding increases.

When the drug interacts with diuretics, the effect of the latter decreases, which means the excretion of sodium and potassium decreases. This is especially important for patients suffering from kidney and heart pathologies.

When taken simultaneously with drugs containing lithium, the toxicity of both drugs increases, and the level of lithium in the blood increases.

Taking Metatrexate and Nimefast may increase the toxic effects of Metatrexate, so monitoring is required.

Salicylic and valproic acid are able to displace nimesulide and prevent it from binding to plasma proteins, which may result in an increased amount of nimesulide in the plasma.

The combined use of anti-inflammatory drugs and clavulanic acid, antifungal agents and antibacterial agents is contraindicated, as toxic damage to the liver is possible.

The drug is stored in a cool, dark place, away from direct sunlight and children, at a temperature below 25°.

What does Nymefast help with?

The use of nimesulide may impair female fertility and is not recommended for women planning pregnancy, having difficulty becoming pregnant, or undergoing examination for infertility. Like other NSAIDs that are known to inhibit prostaglandin synthesis, nimesulide can cause premature closure of the ductus arteriosus, pulmonary hypertension, oliguria, oligoamnion, increased risk of bleeding, weakness of labor and the development of peripheral edema. There have been isolated cases of renal failure in children of women taking nimesulide in late pregnancy. Use during lactation Passes into breast milk, therefore, its use during lactation is not recommended.

Are there any analogues of Nymefast?

The list is quite large. They all have the same active ingredient, but are produced by different manufacturing companies, which means they have different prices:

• Nimesulide;
• Actasulide;
• Aponil;
• Ameolin;
• Mesulide;
• Nise;
• Nimesil;
• Nimegesic;
• Nimulid;
• Novolid.

Nimesulide

Nise

Nimesil

Nimulid

Reviews

Sergey “I’ve been taking Nymefast for quite some time. At the same time, I suffer from joint pain, sometimes my legs ache unbearably and it is impossible to sleep, then I save myself with this drug. But since I’m already old, I’m afraid of complications and side effects on the stomach, so I take omeprazole at the same time as Nymefast. This combination also protects against joint pain and prevents stomach ulcers!”

Georgy “My friend decided to stop drinking, of course, not on his own, with the help of doctors, and so he began to experience withdrawal symptoms, to relieve which the doctors prescribed him Nymefast, since he had terribly strong headaches, he says it helps well. It turns out that you can drink it even after regular alcohol intoxication)"

Lyudmila “All my life I have suffered from pain during menstruation, when I was at school, I didn’t even go to classes, but now I work and no one gives me sick leave for this, so I have to save myself by various means. It has gotten to the point where neither no-spa, nor analgin, nor Tempalgin help anymore. The doctor advised - “Nimefast” is an excellent drug! And the main thing is that the pain goes away after 20 minutes and subsides for a long time, and that’s exactly what I need!”