Osteomed Forte. Osteoprotector. (60 tablets of 500 mg). Parapharm

Content

• 1 Osteomed 1.1 Composition of osteomed

Osteomed[edit | edit code]

Osteomed forte
Osteomed

is a dietary supplement for the treatment of osteoporosis, widely promoted commercially. It has nothing in common with the Osteomed clinic in Obninsk. It is not a medicinal product. The average price of Osteomed forte is 280 rubles.

The Parapharm company is also known for massive spam aimed at advertising the sports supplement Leveton. After writing a revealing article about leveton, Elistratov secured the blocking of the sportswiki.ru website through a local Penza court, allegedly for the distribution and promotion of drugs, thus demonstrating the methods of dirty competition that the company uses. The judgment was made with a number of serious violations and errors.[1][2]

Composition of osteomed[edit | edit code]

Osteomed: composition and description
The supplement is available in 500 mg tablets, which include:

• Calcium citrate – 200 mg
• Vitamin B6 - 0.3 mg
• Drone homogenate (ground drone larvae) – 100 mg

Osteomed forte

supplemented with vitamin D3 (300 IU) - a truly revolutionary solution!

Composition of drone brood (homogenate)

in 1 tablet osteomed:

• Testosterone - 0.003 nmol/g or 0.00000000009 g
• Proteins - 0.01-0.02 g Amino acids - 0.01 g

Osteomed Forte. Osteoprotector. (60 tablets of 500 mg). Parapharm

1.Calcium citrate: best quality and safe quantity

Osteomed Forte contains calcium in its most bioavailable and safe form - citrate, and not in a high, but a moderate dosage. Thus, the digestibility of calcium gluconate is no more than 9%, and calcium carbonate is practically not absorbed with low acidity, which is observed in half of people after 50 years. Both gluconate and carbonate cause serious disturbances in the functioning of the digestive system. Citrate is absorbed into the blood regardless of acidity and does not have the ability to lower it. On average, its ability to be absorbed in the gastrointestinal tract is 2.5 times higher than that of carbonate, and amounts to 44% !

Calcium citrate, due to the ability of citrate acid to alkalize urine, prevents inflammatory diseases of the urinary tract. And the absence of inflammation in them protects against stone formation . In addition, after calcium is absorbed, citrate is included in the Krebs energy cycle, serving to produce additional energy, while carbonate supplies the body with ballast CO2. We also note the absence in the artificially synthesized citrate form of harmful impurities that are possible in carbonate of natural origin.

Now about the dosage. With the recommended dosage regimen (2 tablets in the morning + 2 tablets in the evening), a person receives only 1000 mg of calcium citrate, or 211 mg of pure calcium per day. It would seem that this is not enough considering the WHO recommendation to consume 1000–1500 mg of calcium per day. But the macroelement calcium is by no means deficient in ordinary food and even drinking water , and with proper nutrition our body is able to obtain it naturally.

However, in most calcium-containing products, manufacturers do not skimp on adding doses of calcium that completely cover the daily requirement. But the benefit is doubtful! Frequent surges of calcium in the blood increase the risk of heart attack, stroke, kidney stones, gall bladder stones and other complications. But the absorption of calcium by bone tissue remains low, since there are simply no young bone structures that need mineralization.

That is why the creators of Osteomed Forte pursued the goal not to supply the body with a shock dose of the mineral, but to ensure its transportation to the skeletal system. And this mission was entrusted to the key component of the drug – HDBA organic complex.

2.HDBA organic complex – a guarantee of calcium delivery exactly to the target

HDBA is an acronym derived from the English. Homogenate Drone Brood Adsorbed, which means adsorbed homogenate of drone larvae. This component plays the role of a hormonal activator of bone anabolism. However, its fundamental difference from hormone replacement drugs is its stimulating, rather than suppressive, effect on its own hormone production .

The secret of the rejuvenating effect of drone jelly, noted in ancient Chinese medicine, was revealed only in our days. Scientists - D.V. Mitrofanov, N.V. Budnikova, L.A. Burmistrova - discovered testosterone, estradiol, progesterone, prolactin, as well as gonadotropins - hormones that trigger the production of sex hormones in humans - in this apiproduct. For us, bee hormones act as prohormones - material for creating our own hormones in the proportions we need.

The ability of drone homogenate to increase the activity of the endocrine glands and raise the level of sex hormones, in particular testosterone, was proven in a study by L. A. Burmistrova. This property of HDBA was later confirmed by a number of studies. Particularly valuable is the ability to safely increase the level of endogenous (own) testosterone with the help of drone jelly. After all, it is testosterone that gives impetus to the formation of new bone cells.

In addition, drone homogenate, rich in vitamins and amino acids, provides us with material for the formation of collagen . This fibrillar protein is the basis of all connective tissues, including bone and cartilage. This natural product also replenishes the reserves of minerals (calcium, magnesium, phosphorus, iron, potassium, iodine, etc.) necessary for bone formation.

However, most methods of preserving perishable drone jelly do not make it possible to preserve the hormonal activity of this product. The solution to this problem was the invention of a technology patented by Parapharm for the adsorption of homogenized brood of drone larvae on lactose and glucose, followed by vacuum drying without a temperature difference.

3.Vitamin D3 (cholecalciferol) – calcium conductor

Vitamin D ensures the absorption of bone mineral from the intestines into the blood. When there is a deficiency, the bulk of calcium entering the body passes through transit. In principle, we obtain this vitamin from food and produce it in the skin under the influence of direct sunlight. However, its additional intake is justified by the low content of foods rich in it in the diet of many people and the low level of insolation in most of the territories of Russia.

Of the two biologically active forms of vitamin D, it is preferable to take vitamin D3 (cholecalciferol) in supplement form. Unlike the D2 form, it is less toxic in overdose, more stable and easier to absorb by the body. In general, its efficiency is 30% higher than that of D2.

4.Vitamin B6 (pyridoxine hydrochloride)

This important participant in mineral metabolism promotes the absorption of magnesium in the intestines and its entry into cells. And magnesium is necessary for the proper distribution of calcium in the body, directing calcium to bone tissue and concentrating it in it, and not in the blood, blood vessels and soft tissues.

With a lack of vitamin B6, the formation of collagen, the basis of the bone matrix, slows down, which means the restoration processes in the bones slow down.

Efficiency[edit | edit code]

Center for Innovative Technologies Parapharm LLC (Kalinina St. 116a)
Elistratov in an interview with PenzaNews reports:

“This drug is 10 times better than Western analogues. Last year the regional government provided us with great help. It supported us financially. We used these funds to patent Osteomed in 35 countries with a total population of more than 4 billion people. Therefore, the potential is huge"

[3]

Promotion of supplements[edit | edit code]

The development and promotion scheme for supplements from Parapharm is always approximately the same.

Mechanism of action[edit | edit code]

According to Elistratov, drone brood is a donor of the hormones estradiol, prolactin, testosterone, progesterone and many other useful substances that make osteomed “a world discovery in the field of osteoporosis treatment.”

Research[edit | edit code]

Calcium salts have been used to treat osteoporosis for many years and these drugs are available at extremely low prices. The same is true for vitamin D3 and B6. It should be noted that an independent 2015 clinical study published in JAMA Internal Medicine found that vitamin D supplements did not protect against fractures or have a protective effect on bones in postmenopausal women.[4]

Calcium supplements are ineffective.

Researchers from the University of Auckland decided to test the claim that calcium supplements strengthen bones. It turned out that this is a myth, but only for older people. For their findings, the scientists drew on data from two large studies that looked at older people. Using a data set of 45,000 respondents, it was found that taking calcium supplements had no effect on the incidence of fractures. Another study included 13,790 men and women over 50 years of age. According to him, taking calcium supplements increases bone strength by only 1-2%.

The authors draw a logical conclusion: a normal healthy diet provides our bones with a sufficient amount of calcium, and taking additional medications with it will not provide anything additional.

The estrogenic effect of drone milk is lower than that of soy. The androgenic effect is also low

Drone brood.

It is known that the content of hormone-like substances in drone brood, homogenate or royal jelly is extremely low.[5]

Studies[6] have been conducted to determine the effectiveness of drone jelly and artificial estrogens in an experimental model of uterine evolution:

• 17b-estradiol valerate (3.9 mg/kg) - increased uterine volume by 70%
• Drone jelly (570 mg/kg) contributed to an increase of only 10%, although the dose was 146 times higher than the reference product. For a human, the equivalent dose would be 57 grams, or a few tablespoons.

Research sponsored by Parapharm[edit | edit code]

Relatively recently, medical universities and research centers announced a competition for the best research work on the clinical use of the drugs Osteomed, Osteo-Vit (D3, B6) and Osteomed forte.[7] It should be noted right away that these supplements do not yet have any right to be called drugs. Researchers, interns, clinical residents, graduate students, and practicing doctors in Russia and the CIS countries for whom the state cannot provide decent wages are invited to participate in the competition.

The competition committee consists of 7 high-ranking people. Three awards are established in each category:

• 1st prize – $10,000
• 2nd prize – $3000
• 3rd prize – $1000

Works that do not win prizes, but are positively noted by members of the competition committee, are awarded incentive prizes - $500 (10 prizes in total). The deadline for submitting works for the competition is July 1, 2015.

Conclusion[edit | edit code]

Thus, since the fall of 2015, one can see how domestic science is discrediting itself for commercial purposes.

The great philosopher Seneca also wrote: science ceases to be a good when its fruit is money.

Where does calcium go and how to get it back?

The reason for the removal of calcium from the body lies in hormonal changes. Hormones regulate metabolic processes, anabolism and catabolism - biosynthesis and tissue destruction. Testosterone is recognized as the main anabolic hormone ; it plays a leading role in the creation of all types of connective tissue. And teeth, skin, hair, nails, bones and articular cartilage are all types of connective tissue!

As we age, the production of sex hormones decreases. Moreover, in women this happens earlier and more sharply. After 40–45 years, not only the production of estrogen decreases, but also testosterone, which is initially 10–20 times less in the female body.

Menopause deals a severe blow not only to reproductive health, but also to a woman’s skeletal system. At the same time, teeth decay, hair and nails lose their shine, becoming fragile, as hormonal changes cause an imbalance of mineral substances, and first of all, a disturbance in phosphorus-calcium metabolism.

Preparations with calcium and vitamin D 3 , which forces the body to absorb calcium, would seem to solve the problem of a lack of this important macronutrient. Indeed, CaD3 ensures the flow of calcium into the blood, which in itself poses a threat of hypercalcemia, vascular calcification, kidney stone formation, etc. But, alas, this formula is not capable of driving the mineral into the above-mentioned depots due to the lack of young cells in them necessary for its absorption (mineralization). Thus, the bones, where 99% of calcium should be concentrated, do not accept it when, due to a drop in the level of the anabolic hormone testosterone, the production of young bone cells - osteoblasts - decreases.

The balance of calcium and other minerals can be leveled only by normalizing hormonal levels, and first of all, by increasing testosterone. How to do this safely, without resorting to dangerous hormone replacement therapy?

XVIII All-Russian Conference and Osteomed[edit | edit code]

Award ceremony and announcement of cash prizes

XVIII All-Russian Conference, October 1 - 3, 2015, Russia, Rybnoye, Ryazan Region, Federal State Budgetary Institution "Research Institute of Beekeeping". The conference was sponsored by . Below is an analysis of the winners' reports.

1st place: Sarvilina Irina Vladislavovna[edit | edit code]

Sarvilina Irina Vladislavovna
Regalia:

Doctor of Medical Sciences, clinical pharmacologist, professor, member of the Interregional public organization "Society of Pharmacoeconomic Research", member of the Rostov Scientific Society of Pharmacologists, member of the Board of the All-Russian Scientific Society of Toxicologists, member of the international council of experts of the ROMUALDO DEL BIANCO Foundation (Italy), member of the Rostov Regional Association managers and specialists of small enterprises. Chief physician of the commercial clinic Novomedicina LLC, Rostov-on-Don

Subject:

Study of the molecular mechanisms of the effectiveness of the drug "Osteomed-forte" in psoriatic arthropathy.

Report by Sarvilina Irina Vladislavovna

Diploma presentation

Criticism

• Firstly, Irina Vladislavovna Sarvilina positions Osteomed Forte as a drug, although it is not one.
• The speaker states that when analyzing synovial fluid while taking Osteomed, a decrease in the concentration of the defensin-1 protein is observed, but the protein is characterized by her as a promising antibiotic. Further logic is completely lost. Defensin-1 is a component of drone brood, and when consumed, a decrease in this protein in the synovial fluid is observed. That is, consuming a supplement with defensin-1 causes a decrease in its concentration.
• But the biggest stupidity is that proteins are not absorbed unchanged when ingested, but are broken down into amino acids.
• The report also lacks statistical significance, which is unacceptable in science.

Irina Vladislavovna received 500 thousand rubles

!

2nd place: Oksana Aleksandrovna Ismailova[edit | edit code]

Ismailova Oksana Aleksandrovna
Regalia:

Graduated from Saratov State Medical University, clinical residency and internship at the State Educational Institution of Further Professional Education, PIUV Roszdrav. Since 2009, senior laboratory assistant at the Department of General Dentistry and Therapeutic Dentistry. 2012 - Assistant at the Department of General Dentistry, Therapeutic Dentistry and Pediatric Dentistry at the Penza Institute for Advanced Medical Studies, where the supplement was developed.

Subject:

Features of the treatment of inflammatory periodontal diseases in women in the postmenstrual period, taking into account the mineral density of bone tissue.

Report by Oksana Alexandrovna Ismailova

Criticism

• Osteomed forte is positioned as a drug, although it is not one.
• Makes an unfounded conclusion that Osteomed forte is “one of the most effective and pathogenetically substantiated drugs for osteotropic therapy.”
• Oksana Aleksandrovna Ismailova calls treatment with Osteomed a method. In science and medicine, a method is a way of knowing or obtaining knowledge, and what is shown in the study is nothing more than a banal therapy scheme.
• No statistical significance was demonstrated.

Profit:

150 thousand rubles.

3rd place: Kuptsova Tatyana Anatolyevna and others[edit | edit code]

Kuptsova Tatyana Anatolyevna, Penza Institute for Advanced Medical Studies. Head Strukov Villoriy Ivanovich.

Subject:

"Osteo-vit D3" in the treatment of children with repeated bone fractures due to osteoporosis.

Report by Tatyana Anatolyevna Kuptsova

Criticism:

there is no statistical significance and there is no placebo control group, which does not allow assessing the validity of the results and is unacceptable for clinical studies. As a result, the study's conclusions are completely unfounded.

Also 3rd place was given to Nadezhda Vyacheslavovna, Anton Sergeevich and Pavel Mikhailovich, whose reports were not even presented at the conference.

Profit:

50 thousand rubles to each winner.

Calcium is an essential mineral for health and an essential element of beauty.

A white-toothed smile and radiant skin, strong shiny hair and strong well-groomed nails, correct posture and a confident gait are integral attributes of beauty. Do you know what binds this whole bouquet together, preventing it from withering?

The macroelement calcium is the basis of bone tissue, teeth and one of the most important components in hair and nails; it also protects epithelial cells, being part of the repetin protein. All this allows us to call calcium not only the most important mineral for health, but also an indispensable element of beauty. But with age, it increasingly leaves its main depots - bone matrix, dental tissue, hair and nails. Why?