Pharmacodynamics and pharmacokinetics
The active ingredient meloxicam is a derivative of oxicam . It has an anti-inflammatory effect by blocking the synthesis of prostaglandins and the enzyme cyclooxygenase-2 , which takes part in the arachidonic acid .
Under the influence of meloxicam, the activity of mediators of the inflammatory process and the permeability of vascular walls reactions with free radicals are inhibited . Pain relief occurs due to a decrease in the activity of interaction between prostaglandins and nerve endings .
A steady-state maximum concentration is achieved within three to five days. It binds well to proteins in blood plasma (99% and above). Metabolized in the liver, forming 4 metabolites. They do not play a role in pharmacodynamic processes. Metabolites are excreted in feces and urine over a period of 15 to 20 hours.
Pharmacological action and beneficial properties
All therapeutic effects of Artrosan are based on the action of meloxicam. It selectively blocks cyclooxygenases, enzymes responsible for the synthesis of mediators of pain, swelling and inflammation. They are the causes of all discomfort. The Artrosan injection has a diverse effect on the sore joint:
- reduces the severity of pain;
- eliminates crunching and clicking sounds that occur when bending, turning, bending and straightening joints;
- relieves acute, subacute, chronic inflammatory processes;
- resolves swelling that impinges on nerve roots;
- increases range of motion in joints and spine
Reducing inflammation leads to improved blood circulation. Oxygen and nutrients begin to flow into damaged tissues, starting their recovery processes.
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Contraindications
- drug allergies or special sensitivity to the components of the drug, including the NSAID ;
- stomach and duodenal ulcer;
- bronchial asthma;
- polyps in the nose and nasal cavity;
- bleeding and (or) hemorrhage in the stomach, intestines, etc.;
- severe forms of heart, kidney and liver failure;
- age up to 15 years;
- hemophilia;
- hyperkalemia;
- pregnancy and lactation.
Side effects
Possible occurrence:
- indigestion , belching , stomach bleeding , and stomach ulcers;
- hepatitis , increased levels and activity of liver enzymes , acute renal failure ;
- bronchospasm , angioedema , peripheral edema ;
- leukopenia, thrombocytopenia, anemia;
- tachycardia, anaphylaxis;
- esophagitis, allergic skin reactions, photosensitivity and itching ;
- headache, drowsiness , dizziness , disorientation and blurred vision ;
- stomatitis, conjunctivitis and urticaria .
Possible side effects
Failure to follow the rules of asepsis when performing an injection at home will cause infection of the soft tissues. Its typical symptoms are redness of the skin at the site of needle insertion and inflammation. Artrosan itself is capable of provoking negative reactions from all vital systems. They manifest themselves with the following symptoms:
- sore throat, unproductive dry cough;
- confusion;
- headaches, dizziness, impaired coordination of movements;
- tinnitus;
- sleep disorders - drowsiness or insomnia;
- hematuria, interstitial nephritis;
- urinary tract infections;
- renal medullary necrosis;
- surges in blood pressure;
- tachycardia;
- epigastric pain, attacks of nausea and vomiting;
- diarrhea or constipation;
- dry mouth, change in taste.
Any side effect of Artrosan should be a signal for immediate consultation with a doctor. Symptomatic treatment will be carried out, therapeutic regimens will be adjusted, and replacement will be made with an analogue with another active substance.
Instructions for use of Artrosan (Method and dosage)
The tablets are taken once a day with food and water. The recommended daily dose is from 7.5 mg to 15 mg, depending on the intensity of the pain syndrome and the course of the disease.
If the drug cannot be taken orally , intramuscular injections .
Artrosan injections, instructions for use
Artrosan injections are prescribed for acute pain during the first few days of illness. Injections of the medicine are made intramuscularly , deep into the tissue. The daily dose ranges from 7.5 to 15 mg, with therapy starting with small doses and increasing until the desired effect is achieved.
Do not exceed the recommended dosage, as this may increase the risk of side effects.
Distinctive features of Artrosan
Artrosan is a well-known representative of the clinical and pharmacological group of nonsteroidal anti-inflammatory drugs (NSAIDs). It often becomes the drug of first choice in the treatment of inflammatory and destructive-degenerative diseases of the joints and spine in adults. Artrosan differs from other NSAIDs in its selectivity.
The drug affects only the joints affected by pathology, while other drugs also affect internal organs.
An Artrosan injection is used when a person’s health suddenly deteriorates. Pain, stiffness, and swelling take you by surprise, so immediate consultation with a doctor is unlikely. If you have a syringe and an Artrosan ampoule at home, you can inject it without any problems.
Interaction
When combined:
- with blood pressure-lowering drugs, their effectiveness decreases;
- with diuretics and cyclosprorine , the risk of renal failure increases significantly;
- with vitamin K antagonists , fibrinolytics , heparin, serotonin reuptake inhibitors - bleeding may occur.
Combine with caution with intrauterine contraceptives , lithium preparations , cholestyramine , other NSAIDs , methotrexate .
special instructions
The use of medication can mask infectious diseases occurring in the body.
When using the product for more than 14 days, liver and kidney functions should be monitored.
If the patient has a predisposition to stomach and duodenal ulcers, Artrosan should be used with extreme caution.
If effects associated with a decrease in the speed of psychomotor reactions , working with machinery and driving vehicles should be stopped for a while.
When are NSAID injections needed?
The main indications for Artrosan therapy are inflammatory and degenerative pathologies of the joints and spine. It is prescribed to patients with pain, stiffness, and inflammatory swelling. The non-steroidal anti-inflammatory drug is also in demand in the treatment of myositis and various neuralgia. Arthrozan is included in therapeutic regimens when diagnosing such diseases in acute form:
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- cervical, thoracic, lumbosacral osteochondrosis;
- hernial protrusion of any localization;
- uncovertebral syndrome;
- ankylosing spondylitis;
- rheumatic fever;
- radiculitis;
- sciatica, lumbago;
- gout;
- osteoarthritis.
The use of an injection solution is also practiced in the postoperative period to eliminate inflammatory edema that compresses sensitive nerve roots.
Doctors prescribe the drug for bursitis, tendinitis, tendovaginitis, muscle ruptures, and damage to the ligamentous-tendon apparatus.
Artrosan injections help to quickly get rid of pain and during exacerbations of chronic synovitis that occur due to excessive accumulation of synovial fluid.
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Artrosan's analogs
Level 4 ATX code matches:
Mirlox
Revmoxicam
Xefocam Rapid
Xefocam
Movalis
Mesipol
Lem
Melbek
Movasin
Piroxicam
Lornoxicam
Texamen
Amelotex
Meloxicam
Analogues of Artrosan are: meloxicam, mataren, Melbek, medsikam, movalis, bi-xicam, Lem, m-cam, Movasin, mesipol, mirlox, amelotex, meloxam, melox, meloflam, movix .
The best substitutes for Artrosan
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The pharmacy assortment contains many structural analogues of Artrosan with meloxicam in injection form. If necessary, it is replaced with Movalis, Movasin, Mesipol, Amelotex, Meloxam, Movix. The most inexpensive analogue is Meloxicam solution. It costs 1.5-2 times less than Artrosan (from 220 rubles).
A drug | Manufacturer | Active substance | Cost, in rubles |
Voltaren | Novartis Pharma (Switzerland) | diclofenac | from 200 |
Diclofenac | OZON LLC, Tatkhimfarmpreparaty OJSC (Russia) | diclofenac | from 100 |
Ketorol | Dr. Reddy`s Laboratories Ltd., India | ketorolac | from 150 |
Ortofen | VERTEX (Russia), Biokhimik (Russia) | diclofenac | from 100 |
Ketonal | Novartis Neva | ketoprofen | from 230 |
Artrosan price, where to buy
The price of Artrosan 15 mg tablets is 225 rubles for 20 pieces.
The price of Artrosan injections is about 219 rubles for 3 ampoules of 2.5 ml.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Arthrozan solution for intramuscular injection.
0.006g/ml 2.5ml 5pcs JSC Pharmstandard-UfaVITA 371 rub. order - Artrosan tablets 15 mg 10 pcs. Pharmstandard-Leksredstva OJSC
RUB 179 order
- Artrosan tablets 15 mg 20 pcs. Pharmstandard-Leksredstva OJSC
RUB 272 order
Pharmacy Dialogue
- Arthrozan (solution d.vm injected 6 mg/ml 2.5 ml No. 10 bufus) FS-UfaVita
612 rub. order
- Arthrozan (0.006/ml 2.5 ml No. 10) FS-UfaVita
RUR 573 order
- Artrosan (solution d.vm injected 6 mg/ml 2.5 ml No. 5) FS-UfaVita
RUB 391 order
- Artrosan (tab. 15 mg No. 20) FS.-Leksredstva
RUB 267 order
- Artrosan (tab. 15 mg No. 20) FS.-Leksredstva
RUB 253 order
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Step by step guide
Injecting Artrosan at home with the proper skills is as easy as shelling pears. If you have no experience, you should follow these instructions:
- wash your hands with soap, dry, treat with an antiseptic solution, for example, Miramistin;
- open the package with the syringe, wipe the top of the ampoule with an antiseptic, run a special nail file along the notch, and break it;
- insert the needle into the ampoule, draw out the required amount of medicinal solution;
- get rid of air bubbles by squeezing them out with a piston;
- wipe the center of the upper quadrant of the right or left buttock with an antiseptic;
- move your hand back a little and lightly slap the skin;
- insert the needle deeply, press the plunger to empty the syringe;
- remove the needle, press a sterile napkin soaked in any alcohol-containing solution (from alcohol - vodka) to the injection site.
The drug is used once a day. Artrosan is administered only intramuscularly, and mixing it with other drugs is strictly prohibited. You cannot prick twice in the same place, otherwise the risk of swelling increases. If it appears, then an iodine grid will help greatly.