Osteoarthritis is the leader in prevalence among other joint diseases. In world rankings for the incidence of osteoarthritis, Russia, like other post-Soviet countries, is in the top positions: up to 48% of the population suffer from one form or another of the disease. In advanced cases, osteoarthritis leads to disability, disability, and worsens the quality of life. And treating this disease is a costly undertaking. Especially if the disease has progressed to late stages and has significantly affected the cartilage tissue.
Articular cartilage and intervertebral discs regenerate even in adults. This process is ensured by the activity of chondrocytes and chondroblasts. When there are enough of these cells in the joint, and they receive enough nutrition with micro- and macroelements, then the cartilage is able to regenerate from the inside. But if (due to illness or age) cell metabolism is disrupted, and synovial fluid, the main source of nutrients, is not produced in the required quantities, then cartilage needs outside help. For these purposes, pharmacology identifies a group of drugs - stimulants and correctors of metabolism in cartilage and bone tissues. Piaskledin also belongs to these drugs.
Mechanism of drug action
According to the instructions for Piaskledin 300, the product belongs to herbal preparations. The main purpose is to regulate metabolism in cartilage tissues.
Taking capsules helps:
- relieving pain and inflammation in joints;
- inhibition of destructive processes in cartilage;
- restoration of motor activity;
- stimulating collagen production in joint tissue cells.
The medicinal effect occurs due to unsaponifiable compounds of avocado oil and soybeans, which:
- increase the volume of collagen produced in cartilage tissues, due to which their firmness and elasticity increase;
- reduce the synthesis of collagenase, an enzyme that can break down collagen;
- regulate the activity of plasminogens, thereby preventing the destruction of cartilage tissue;
- promote the synthesis of periodontal tissue and serve as a preventive measure for tooth loss.
The unsaponifiable part of the oil contains vitamins, carotenoids, minerals, acids, phytosterols and other biologically active substances. The presence of unsaponifiable lipids helps suppress the inflammatory process that accompanies the destruction of cartilage tissue when affected by arthrosis or arthritis.
Problems of drugs for the treatment of arthrosis
Now, with the dominance of all kinds of chemistry, there is great interest in plant-based preparations. We all understand this when choosing and buying medications for ourselves. Modern medications, especially NSAIDs, in addition to their intended purpose, also have serious side effects. Avoiding this wouldn't be bad at all.
Scientists are working in several directions: minimizing the negative effects of taking non-steroidal or steroidal anti-inflammatory drugs and searching for safe natural anti-inflammatory and painkillers, increasing their impact and absorption. Here you can remember about curcumin and preparations based on it, boswellia, preparations with bromelain (pineapple extract), etc. These are natural substances with a proven anti-inflammatory and analgesic effect on joints with arthrosis and arthritis.
Nature heals naturally and gently. The beneficial effects often extend to other systems and tissues of the body. But this is a long process. In acute forms and symptoms of diseases, it is better to use such drugs in addition to the main treatment, when it is necessary to spare the body and prevent it from getting used to and suffering from chemical drugs. It is best to take natural herbal preparations as preventive measures, especially if there are grounds for this, prerequisites and predispositions, and strong physical activity. These are not instant healing drugs, but they have their own great advantages and capabilities. This is why most studies include comparisons with conventional NSAID treatment and look at ways to reduce them.
Benefits of Piascledine for athletes
The joints of athletes and people whose work involves heavy physical labor experience increased stress. In addition, playing sports is often accompanied by injuries, inflammation and pain.
You can take Piaskledin 300 to prevent sports injuries to joints and cartilage, to quickly relieve the inflammatory process to prevent it from becoming chronic. For sprains and injuries to the knee and hip joints, the capsules will help you recover faster.
To reduce the severity of inflammation, as well as the natural restoration of the joint and cartilage tissue, Piascledine should be taken in the postoperative period.
Scientific research on unsaponifiable oils (Piascledina)
Piascledine, which contains 300 mg of unsaponifiable oils, is taken once a day. This indicator was calculated through randomized controlled trials (RCTs) of patients with arthrosis of large joints (knees, hips, spine).
An RCT is a type of scientific, most often medical, study in which participants are randomly assigned to two groups. In one group, the effect of the drug is used and studied, while in the other, standard treatment methods or a placebo are used. Sometimes specified as “compared to a placebo group.”
Through such studies, the effect of slowing the progression of the disease after 3 months was proven, as well as reducing the need for non-steroidal anti-inflammatory drugs and a significant reduction in pain was established. Interestingly, the effect still persisted over the next 2 months.
The combination of unsaponifiable oils is, in turn, a combination of many other plant compounds, and so far no one has been able to find out and prove what exactly and how it has a healing effect. Most research favors the beneficial effects of plant phytosterols and a mixture of tocopherols (various forms of vitamin E).
You need to understand that unsaponifiable oils do not cure arthrosis. Studies have shown that their main effect is to reduce and inhibit the negative dynamics in the development of the disease, the destruction of cartilage, inflammatory processes and pain.
The effect of the combination of unsaponifiable oils makes it possible to reduce the intake and harm of NSAIDs (non-steroidal anti-inflammatory drugs), which still remain the main ones for pain relief, but are also harmful in terms of side effects and effects on the body. This effect of oils in reducing dependence or even quitting NSAIDs is considered a huge achievement and benefit of this drug.
According to studies of two groups of patients with the same clinical parameters, after several months of taking piascledine at a dosage of 300 mg/day, the trend in joint space narrowing in the group taking piascledine was 2 times less than in the placebo group.
Reviews
Experts speak positively about the drug: the capsules are highly effective and have a natural composition. Easy to use, as one piece per day is enough. The drug helps reduce pain in chronic diseases of the spine and lower back pain. The disadvantages are the high cost of the course of treatment and the need for long-term therapy, since the drug has a cumulative effect.
Patients note a decrease in pain, swelling of the joints, the disappearance of crunching, the return of the ability to move without pain, and the disappearance of the dependence of the condition on weather changes.
Piaskledin (Piascledin 300) and unsaponifiable oils: instructions for use
The studies used dosages of 300 and 600 mg per day of a combination of oils. As it turned out, the effectiveness of both dosages is the same and there is no point in increasing the doses of Piascledine.
The recommended dose for a combination of unsaponifiable oils (Piascledine) is 300 mg per day: 100 mg - avocado oil, 200 mg - soybean oil. It is enough to take the drug with a combination of unsaponifiable oils once a day.
If this is a complex drug with other components, then it is necessary to ensure that the combination of oils of 300 mg/day is observed when taking it.
Price
Piaskledin cannot be called a cheap and affordable medicine. The price for one pack of the drug containing 30 capsules varies depending on the region. At the same time, in online pharmacies the cost of “Piaskledin” is slightly lower than in offline pharmacies.
In Moscow pharmacies, the price for “Piaskledin” starts at 1,300 rubles per package. The maximum price reaches 1600 rubles. The drug will cost a little cheaper in St. Petersburg - from 1,200 rubles per package. Kazan pharmacies set the price for “Piaskledin” at 1000-1100 rubles, and in Yekaterinburg you will have to pay about 990 rubles for a package.
Since a full course will require 6 packs of the drug, the amount for therapy with Piaskledin will be quite large, and therefore not affordable for every wallet. Considering that among patients with osteoarthritis, the majority are pensioners. Of course, in the case of this medicine, the price corresponds to both the quality and the healing effect. But many people are interested in whether Piaskledin has cheaper analogues.
Data on the production of the drug
- The manufacturer is the French company Expansiance.
- Supplied in capsules with 300 mg of substance.
- 1 blister contains 15 capsules.
- A pack made of cardboard contains 1-2 blisters and instructions.
- 1 capsule contains the following components: 200 mg of the unsaponifiable fraction of soybean oil, 100 mg of the unsaponifiable fraction of avocado oil.
In oils, in their saponified part, the constituent elements are glycerin and fatty acids; they determine how the oil looks externally and its consistency. This fraction has a peculiarity: when alkali is introduced into their composition, soap is formed. If you mix the unsaponifiable fraction of oils with alkali, no soap is formed; they have a different composition and properties.
It is the unsaponifiable fraction of oils that contains such useful substances as:
- phytosterols;
- enzymes;
- acids;
- minerals;
- vitamins;
- carotenoids.
It also contains many other useful elements. For the treatment of joints, as well as for cosmetic procedures, the unsaponifiable fraction of oils is extracted and used. It is the unsaponifiable fraction of the oil that has beneficial pharmacological properties.
Piascledine 300
Capsules contain such auxiliary compounds as:
- colloidal silicon dioxide;
- butylated hydroxytoluene.
Piaskledin 300, patient reviews of which describe it as an effective drug, is sold at different prices in different pharmacies, its cost is approximately 1200-1300 rubles.
Alflutop
Manufacturer: Zentiva, Romania
Release form: injection solution
Active ingredient: bioactive concentrate from small marine fish
Alflutop is an analogue of Piaskledin 300 in ampoules, it is a concentrate from small sea fish of the herring, cod and anchovy families, obtained through extraction and subsequent release from proteins and fats. As a result, amino acids, trace elements, peptides and mucopolysaccharides, including chondroitin, remain in the extract.
Thanks to this unique composition, the Alflutop analogue prevents destruction and promotes the restoration of cartilage tissue.
The anti-inflammatory effect of Alflutop is due to the blockade of the enzyme hyaluronidase, which enhances the formation of hyaluronic acid.
The Alflutop analogue is used in the form of intramuscular or intra-articular injections for osteoarthritis, osteochondrosis and spondylosis.
Artra
Manufacturer: Ameripharma Labs, USA
Release form: film-coated tablets
Active ingredient: Glucosamine + Chondroitin sulfate
Synonyms: Teraflex, Condronova, Artrafik Pro
Artra is a regenerator of cartilage tissue, promotes the restoration of cartilage, and prevents its destruction.
This American analogue of Piascledine is used for various diseases of the musculoskeletal system, accompanied by pain and decreased joint mobility.
In the first 20 days, Arthra is taken one tablet twice a day, then switched to a single dose. The most lasting effect is observed after a six-month course of treatment.
Indications
Indications for taking Piascledine - complex therapy for degenerative joint diseases:
- Osteoarthritis of the hip joints stages 1-3;
- Osteoarthritis of the knee joints stages 1-3;
- Spondyloarthrosis;
- Rheumatoid arthritis;
- Osteoarthritis of the joints of the hands;
- Traumatic joint injuries.
In addition, clinical studies conducted from 1995 to 2013 showed that taking Piascledine has a positive effect on the health of damaged joints of any location. In people suffering from these ailments, a significant reduction in regular pain syndrome is observed after two months of taking the drug.
Another purpose of “Piascledin” is the auxiliary therapy of periodontitis (inflammation of the soft tissues surrounding the roots of the tooth).
How does the medicine for joint regeneration work?
When chondrocyte activity decreases, the synthesis of type II collagen in cartilage tissue decreases. This component is the main building block of cartilage. In addition, in damaged cartilage tissue, the conversion of interleukins and type 2 cyclooxygenase, which causes acute inflammatory processes, increases.
Clinical studies of Piaskledin helped identify the following positive processes in the body:
- Collagen production increases;
- Macromolecules of the intercellular substance of hyaline and articular cartilage are synthesized;
- The production of active compounds that affect the degradation of cartilage tissue is reduced;
- The activity of stromelysin, which can destroy extracellular matrix proteins, decreases;
- The phytosterols contained in the drug have an anti-inflammatory effect, reduce cartilage damage;
- The TFG-beta protein accelerates cell renewal in cartilage tissue.
"Piaskledin" is a chondroprotector, so the main task is to slow down the development of the disease. But the drug also has a symptom-modifying effect, that is, it reduces pain.
Piaskledin or Piacartil - which is better
Manufacturer: Omegapharma, Russia
Release form: capsules
Active ingredient: soy protein isolate, mixture of avocado and soy unsaponifiables, silicon dioxide, mixture of tocopherols
Piacartil is a dietary supplement containing a proprietary blend of AvoVida® containing soy and avocado unsaponifiables, soy protein isolate, silicon dioxide and vitamin E.
The dietary supplement is close in composition to Piascledine, but you need to remember that this is not a medicine and is used for the prevention of joint diseases or in complex therapy together with medications - chondroprotectors and NSAIDs.
Pyacartil is used one capsule per day for at least one month. If necessary, you can take the course or repeat it regularly up to 4 times a year.
Analogs
In the register of medicines of the Russian Federation (RLS), "Piaskledin" is included in the extensive group of "Correctors of bone and cartilage tissue metabolism." Among drugs with similar effects, there are many names that are both more expensive and available for purchase by people with average and low incomes. Let's consider the most effective and well-proven analogues:
- "Teraflex Advance". Capsules produced by the famous German concern "Bayers". Available in packs of 30, 60 and 120 pieces. The medicinal effect is similar to “Piaskledin”, but the compositions differ. "Teraflex" contains chondroitin and glucosamine. These components have a positive effect on the health of the cartilage matrix, and are included in most modern medications for joints. In addition, this analogue contains ibuprofen, due to which the medicine also has an antipyretic effect and relieves pain. For 30 Teraflex capsules you will have to pay from 780 rubles. A larger package is much more profitable, because 120 capsules will cost 2,200 rubles. In old age, this remedy can be used only after consulting a doctor and with some restrictions.
- "CONDROnova". Despite the different compositions and active ingredients, this drug is identical in action to Piaskledin, and accordingly, it is often used as a complete analogue. Condronova is produced in India. Available in packs of 30 capsules. Like most joint medications, this medication contains chondroitin and glucosamine. Contraindications include individual intolerance and renal failure; in some cases, CONDRONOVA causes drowsiness and gastrointestinal disturbances. For a package of this analogue in pharmacies they ask from 420 rubles. A very good option for pensioners and people with low incomes, as it has no contraindications for use in old age.
- "Arthra". Another drug based on glucosamine and chondroitin, this time made in the USA. In addition to stimulating restoration processes in cartilage tissue, Arthra also protects joints from the side effects of non-steroidal anti-inflammatory drugs used to relieve pain. Long-term systematic use of this analogue of “Piascledin” reduces not only degenerative processes in joint tissue, but also the need for analgesics. If kidney function is impaired, use is contraindicated. The cost of a package of 30 tablets starts from 880 rubles.
- "Alflutop". The injection solution contains extracts of sea fish containing minerals and amino acids necessary for healthy joints. The drug normalizes the synthesis of hyaluronic acid, stimulates recovery processes in the body and relieves pain in the affected joint. This analogue cannot be called cheap. Since the course of treatment is much shorter than that of Piaskledin, and the drug itself is administered intramuscularly and intraarticularly, therapy with Alflutop will be more profitable. One package contains 10 ampoules of the drug. 20 injections will be enough for the course. The cost of packaging is from 1,500 rubles in online pharmacies. It is completely harmless to use Alflutop in old age, but caution should be exercised if there are problems with the kidneys or liver.
- "Rumalaya." Calling this analogue a medicine is not entirely true. This is a dietary supplement based on herbal extracts. Extracts and powders of herbs and plants traditionally used in folk medicine in India produce an effect similar to Piaskledin: they restore the metabolism of cartilage tissue. According to assurances, it relieves inflammation and pain. Contraindicated for pregnant, lactating women and people with hypersensitivity to the components. This analogue is also available in gel form. It is impossible to say for sure whether Rumalaya can become a full-fledged analogue of medicines, so consult your doctor before taking it. The price of a package of 60 capsules is from 360 rubles. The gel will cost 265 rubles.
Side effects
Allergies sometimes occur during drug therapy. Even more rarely, laboratory parameters may increase, including: gamma-glutamyl transpeptidase, bilirubin, alkaline phosphatase and transaminases.
The medicine can be used in work that requires high concentration and high speed of psychomotor reactions.
Piaskledin 300 reviews from patients are described mostly positively. In clinical studies, according to their assessment, the drug was excellently tolerated - in 84.7%, well - in 8.7% and satisfactory - in 6.6%.
In this regard, the researchers concluded that Piaskledin 300 is an effective therapeutic agent with a slow but powerful development of pharmacological effect in the treatment of osteoarthritis. This drug is considered a biological response modifier with a specific mode of action on body tissue.
Piascledine significantly reduces pain in diseased joints, both during the patient’s physical activity and at rest, reduces synovitis, helps reduce the severity of coxarthrosis and gonarthrosis, reduces the need to use NSAIDs, and helps maintain the functionality of diseased joints.
Piascledine also has a significant modifying effect on the structure of joint tissues; this was established during continuous treatment of coxarthrosis for 2 years.
This medication has high safety and good tolerability. Those few side effects that may appear at the beginning of therapy completely disappear with continued treatment, without requiring a change in the treatment regimen.
The data presented have been proven in a large number of controlled studies that fully meet the requirements for modern medications used to treat osteoarthritis.
Instructions
The medicine is taken orally, 1 capsule per day, it is better to take it during meals, in the morning. Take with 1 glass of water. Therapy lasts six months (6 months). Only a medical specialist can increase the duration of the course of therapy and prescribe additional ones.
Piaskledin 300 has active ingredients with a pharmacological effect, which makes it possible to reduce the dosage of NSAIDs, which are now the main medications in medical practice for the treatment of pain, but, according to doctors, at the same time, have some harmful effects on the patient’s body.
A similar effect of Piascledine in reducing dependence or quitting NSAIDs is a big advantage of this drug.
