The effect of the drug is due to the action of the active components:
- Methylsulfonylmethane (MSM) is a source of sulfur, biologically available to the body, a component of proteins that make up all connective tissues. MSM reduces the risk of developing inflammatory processes, accelerates the synthesis of collagen proteins and helps maintain healthy joints.
- Glucosamine and chondroitin sulfate take part in the synthesis of connective tissue. Glucosamine is a structural component for the formation (synthesis) of other components of cartilage structures, inhibits the development of degenerative processes in joints, and restores their function. The introduction of exogenous glucosamine enhances the production of cartilage matrix. Chondroitin sodium sulfate is an additional substrate for the formation of a healthy cartilage matrix; it is part of the synovial fluid, which ensures the sliding of articular surfaces and also provides nutrition to the cartilage.
- Hyaluronic acid is part of the joint fluid, where it acts as a lubricant, reducing friction between articular surfaces, is part of cartilage, where it performs a “spring” function (maintains the resistance of cartilage tissue to compression), is an important component of synovial fluid, determining it in viscosity - elastic properties. It forms a covering layer on the entire inner surface that protects articular cartilage and synovium from mechanical damage, as well as from free radicals and inflammatory factors. On the surface of the mucous membranes, hyaluronic acid forms a thin semi-permeable protective layer, covering the nerve endings and preventing irritation; stimulates collagen formation.
Pharmacological properties of the drug Artron triactiv
The drug stimulates the regeneration of cartilage tissue. Glucosamine and chondroitin take part in the biosynthesis of connective tissue, preventing the processes of cartilage destruction and stimulating tissue regeneration. Glucosamine enhances the production of cartilage matrix and provides non-specific protection against chemical damage to cartilage. Glucosamine is part of the endogenous glycosaminoglycans of cartilage tissue. Another likely function of glucosamine is the protection of damaged cartilage from metabolic destruction caused by NSAIDs and corticosteroids, as well as its own moderate anti-inflammatory effect. Chondroitin sulfate sodium, regardless of whether it is absorbed in intact form or in the form of separate components, serves as an additional substrate for the formation of a healthy cartilage matrix. Stimulates the formation of hyaluronic acid, the synthesis of proteoglycans and type II collagen, and also protects hyaluronic acid from enzymatic breakdown (by inhibiting the activity of hyaluronidase) and from the damaging effects of free radicals. Chondroitin sulfate maintains the viscosity of synovial fluid, stimulates cartilage repair mechanisms and inhibits the activity of enzymes (elastase and hyaluronidase) that break down cartilage tissue. In the treatment of osteoarthritis, it reduces the severity of symptoms of the disease and reduces the need for NSAIDs. Methylsulfonylmethane is a substance containing sulfur. Sulfur promotes the absorption of minerals by the liver, is important for brain function, the formation of hair, nails, connective tissue, cartilage, and has a pronounced antiallergic effect. Methylsulfonylmethane helps remove lactate from tissues, as well as toxins, which increases and promotes the penetration of nutrients into tissues; Helps the body restore damaged skin cells and connective tissue, increases their elasticity. The bioavailability of glucosamine when administered orally is 25% (first pass effect through the liver). Distributed in tissues: maximum concentrations in the liver, kidneys and articular cartilage. About 30% of the dose taken is stored for a long time in bone and muscle tissue. Excreted primarily in urine unchanged; partly with feces. The half-life is 68 hours. When chondroitin sodium sulfate is administered orally in a single dose of 0.3 g, its concentration in the blood plasma increases sharply over 24 hours. Absolute bioavailability is 12%. About 10 and 20% of the dose taken is absorbed in the form of high and low molecular weight derivatives, respectively. The approximate volume of distribution is about 0.44 ml/g. Chondroitin sulfate sodium is metabolized by desulfuration (after administration of low molecular weight chondroitin sulfate sodium). Excreted in urine. The half-life is 310 minutes.
Compound
Two tablets contain:
- Glucosamine hydrochloride – 1000 mg (mg)
- Chondroitin sulfate sodium – 800 mg (mg)
- Methylsulfonylmethane - 600 mg (mg)
- Hyaluronic acid – 20 mg (mg)
Glucosamine hydrochloride, sodium chondroitin sulfate, methylsulfonylmethane, filler - microcrystalline cellulose, filler - croscarmellose sodium, stabilizer - dicalcium phosphate dihydrate, purified water, tablet shell (filler - hydroxypropyl methylcellulose, stabilizer - polydextrose, dye - titanium dioxide, anti-caking agent - talc, maltodextrin , dye - yellow iron oxide, medium triglycerides, red iron oxide), stabilizer - stearic acid, sodium hyaluronate, stabilizer - magnesium stearate, anti-caking agent - silicon dioxide.
Indications for use of the drug Artron triactive
Diseases of the joints and spine (including osteoarthritis, which is accompanied by synovitis, osteochondrosis); damage to joints of autoimmune origin (rheumatoid arthritis); prevention and treatment of joint damage due to physical overload (sports injury); degenerative-dystrophic diseases of peripheral joints; for ligament injuries, bursitis, tendovaginitis. It is also recommended to prescribe during the period of convalescence after bone fractures (to accelerate the formation of callus), injuries, and operations on the musculoskeletal system.
Contraindications
Should not be used in case of individual intolerance to the components of the product, children, pregnant or breastfeeding women, or people with renal failure.
Should not be used as a substitute for a complete diet. This product is not intended to diagnose, treat, cure, or prevent any disease and should not be used as a substitute for various diets. Do not exceed recommended amount for daily consumption. Do not consume after the expiration date stated on the package. Consultation with a physician is recommended before use.
Instructions for use
The regimen for taking the drug depends on the severity of the patient’s condition, the rate of progression of the disease and individual indicators. It is best to contact your doctor to determine the optimal dosage. Adults and children over 15 years of age take 1-3 tablets per day, depending on the severity of the condition. It is recommended to use the maximum possible dosage in the first days after an exacerbation of the disease, subsequently reducing it for maintenance therapy.
The tablets must be swallowed whole, without chewing or crushing. Drink with a small amount of water. The estimated course of treatment is at least six weeks. To achieve maximum effect, Artron Triactiv should be used for two to three months.
Analogues of the drug
The active substance, chondroitin, has many suitable analogues. The prescription of analogues for the most part occurs based on personal preferences and positive experience with a specialist. It should be noted that independent selection of analogues will not be justified, because there is a high risk of incompatibility of the drug with other components of drug therapy.
Suitable analogues:
- Alit;
- Arthron Chondrex;
- Nanogan;
- Negan;
- Nimuspaz;
- Movex asset;
- Mucosat;
- Teraflex;
- Oxygen;
- Sigan.
Before using any of the above-described remedies, you should consult your doctor and study the instructions for the drug.
Application of Artron Triaktiv
helps eliminate and prevent pathological degenerative processes in joint tissue. It is used for inflammatory diseases, as well as to prevent the development of serious pathologies. How to properly use Artron Triactiv Forte, its instructions and reviews - you will find all the necessary information here.
Area of use and mechanism of action
The Triactive disinfectant is used to treat seed material of grain crops and rice: winter and spring wheat and barley. It is effective against the following pests and diseases:
- Powdery mildew.
- Rust.
- Pyrenophorosis.
- Septoria.
- Fusarium.
- Ear lesions.
- Spotting.
- Golovni.
- Root rot.
- Mold.
- Rhynchosporiasis.
Due to the content of three components, the drug has a complex effect on various pathogens. Its action is based on inhibition of mitochondrial respiration in infected cells. As a result of exposure to Triactiv, spores stop germinating, the mycelium stops growing, the pathogen does not form spores and dies. The remaining two components act systemically, suppress the synthesis of ergosterol, act on the cell membrane and provoke the death of the pest.
How to protect yourself when using
"Triaktiv" belongs to the 2nd class of danger for humans and to the 3rd class for bees. This means that the product poses a serious threat to human health. The drug may pose a threat to pollinating insects if it is sprayed during the active summer of bees. That is why spraying is allowed in the early and late hours, when insects do not fly.
The drug may be toxic to fish and aquatic life, so spraying it near water bodies is prohibited.
In order not to get hurt when using Triactiv, you need to take the following protective measures:
- Wear closed work clothes.
- Use personal protective equipment: mask or respirator, goggles, rubber gloves.
- If the product gets on the skin, mucous membranes, or eyes, rinse the affected area with running water.
- After completing the treatment, wash with soap, take a shower, and change clothes.
If your health worsens as a result of using the drug, it is recommended to seek medical help.
Artron Triactive Plus tab. p/o N60 - Instructions
Release form
Tablets, 60 pieces per pack.
Compound
1 film-coated tablet of Artron Triactiv Plus contains: Chondroitin sulfate sodium – 800 mg; Glucosamine hydrochloride – 1000 mg; Methylsulfonylmethane – 600 mg; Hyaluronic acid - 20 mg. Excipients.
pharmachologic effect
Artron Triactive Plus is a combination drug containing three active substances - chondroitin sulfate, glucosamine hydrochloride and methylsulfonylmethane. The mechanism of action and therapeutic effects of drugs are based on the pharmacological properties of the active components included in their composition.
Chondroitin sulfate – has a pronounced chondroprotective and analgesic effect, improves the metabolism of calcium and phosphorus in connective tissue, inhibits the activity of elastase and hyaluronidase, which disrupt the structure of the joints. The drug slows down degenerative processes and stimulates the regeneration of cartilage tissue and the formation of intra-articular fluid, enhances the formation of glycosaminoglycans and regulates the metabolism of hyaluronic acid. The drug reduces pain in the joints, increases their mobility, prevents the development of osteoarthritis, and reduces the intensity of the inflammatory process in the joints.
Glucosamine hydrochloride – participates in the formation of glycosaminoglycans, stimulates the regeneration of cartilage tissue, and prevents degenerative changes in connective tissue. Eliminates pain and morning stiffness in patients with various diseases of the musculoskeletal system.
Methylsulfonylmethane - contains sulfur, which is easily absorbed by the body, improves the absorption of micro- and macroelements, stimulates regenerative processes and the removal of metabolic products from the body. Increases the elasticity of connective tissue.
Pharmacokinetics.
After oral administration, the active components of the drug are well absorbed in the gastrointestinal tract. The bioavailability of glucosamine is about 25% (glucosamine is characterized by a first-pass effect through the liver), the bioavailability of chondroitin sulfate is about 12%. Chondroitin sulfate is metabolized by desulfuration. The active components of the drug are excreted primarily by the kidneys, both unchanged and in the form of metabolites. Some glucosamine is excreted unchanged by the intestines. The half-life of glucosamine reaches 68-70 hours, chondroitin sulfate - 310 minutes.
Indications for use
The drug Artron Triactive Plus is used for the treatment of patients suffering from degenerative-dystrophic and inflammatory diseases of the musculoskeletal system, including osteoporosis, osteochondrosis, tendovaginitis, bursitis, arthrosis and spondyloarthrosis; as a prophylactic agent for patients with an increased risk of developing degenerative and inflammatory diseases of the musculoskeletal system; patients with rheumatoid arthritis, as well as during the recovery period after surgery and injuries to the musculoskeletal system; for the treatment and prevention of joint damage during increased physical activity; under various conditions as an additional source of organic sulfur. The drug can be prescribed in combination with non-steroidal anti-inflammatory drugs and glucocorticosteroids.
Directions for use and dosage
The drug is intended for oral use. It is recommended to swallow film-coated tablets whole, without chewing or crushing, with a sufficient amount of water. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually.
Adults and adolescents over the age of 15 years are usually prescribed 1 tablet of the drug 1-3 times a day. After achieving the required therapeutic effect, the dose is reduced to 1 tablet of the drug 1 time per day. The duration of treatment is usually about 3 months.
Side effects
The drug Artron Triactiv Plus is usually well tolerated by patients, but in some cases the following side effects may develop:
From the gastrointestinal tract: nausea, vomiting, indigestion, pain in the epigastric region, stool disorders.
From the central nervous system: headache, dizziness, disturbance of sleep and wakefulness, increased fatigue.
Allergic reactions: skin rash, itching, urticaria, erythema, dermatitis, Stevens-Johnson syndrome, Quincke's edema.
Contraindications
Increased individual sensitivity to the components of the drug. The drug Artron Triactive Plus is contraindicated in patients suffering from phenylketonuria, thrombophlebitis and severe impairment of liver and/or kidney function; having a tendency to bleed; during pregnancy and breastfeeding.
Due to the lack of reliable data on the safety and effectiveness of the drug in children under the age of 15 years, Artron Triactiv Plus is not used to treat patients in this age category. Caution should be exercised when prescribing the drug to patients with alcohol dependence and diabetes mellitus.
Pregnancy and breastfeeding
The drug Artron Triactiv Plus is not prescribed to women during pregnancy. If it is necessary to use the drug during lactation, you should consult with your doctor and decide whether to interrupt breastfeeding.
Interaction with other drugs
When used simultaneously, the drug Artron Triactiv Plus enhances the absorption of antimicrobial agents of the tetracycline group in the gastrointestinal tract. When used in combination, the drug reduces the absorption of antimicrobial agents of the penicillin group and chloramphenicol. When using the drug in combination with non-narcotic analgesics and glucocorticosteroids, dose adjustment of the latter is necessary. When used in combination, vitamin and mineral complexes enhance the therapeutic effect of the drug Artron Triactive Plus.
Overdose
In case of an overdose of the drug Artron Triactiv Plus, patients experienced the development of allergic reactions. There is no specific antidote. In case of overdose, gastric lavage, intake of enterosorbents and symptomatic therapy are indicated.
Storage conditions
It is recommended to store the drug Artron Triactiv Plus in a dry place away from direct sunlight at a temperature of 15 to 30 degrees Celsius. The drug should be stored in its original packaging. The shelf life of the drug, regardless of the form of release, is 3 years.
Composition and release form of the disinfectant
"Triaktiv" is produced in the form of KS - a suspension concentrate, sold in five-liter plastic canisters.
The product contains three active ingredients:
- Azoxystrobin – 100 grams per liter.
- Tebuconazole – 120 grams per liter.
- Cyproconazole – 40 grams per liter.
This drug combines the actions of an insecticide and fungicide, and is a protective and healing agent for contact and systemic action.
Instructions for use of the drug "Triaktiv"
According to the instructions, the Triactive disinfectant is used once to treat seeds before planting, the application rate is 0.2-0.3, the consumption of the drug is 10 liters per ton.
Expert opinion
Zarechny Maxim Valerievich
Agronomist with 12 years of experience. Our best country expert.
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Triaktiv is also used for spraying during the growing season. The application rate of the product is 0.8-1, the consumption of the working composition is 300 liters per hectare. The waiting period before harvesting is 40 days.
“Triaktiv” provides long-term protection against diseases, protects crops from secondary damage, strengthens the plants’ own defenses, stimulates the immune system and helps fight stress. Plants that were damaged during planting due to unfavorable weather conditions, sudden temperature changes, or treatment with toxic drugs, tolerate these stressful situations much easier if they were treated with a disinfectant in the form of grain.
See also
Instructions for use of Orvego fungicide, description of the product and analoguesRead
Reviews about the application
Evgeniy “I go in for sports at a professional level, since my youth I have had the consequences of an injury, and periodically the pain returns. On the doctor’s advice, I started taking Artron Triactive, and after three weeks I felt the first results. The pain in my knees and elbow has become less (these are my “bottleneck” areas). In addition, it became easier to perform some exercises, especially stretching. The course was prescribed - three months, I hope for good results.”
Daria “Osteochondrosis of the cervical spine began” while still in college. Before pregnancy, I decided to take my health seriously, so I received comprehensive treatment from a rheumatologist. Among the prescribed medications was Artron Triactive. At first, the effect was noticeable, the pain when moving and sitting in one place for a long time became noticeably less, but the expected healing did not happen. Quite by chance I saw the same drug in the pharmacy, but only in a slightly modified package. After a short “investigation”, it turned out that all this time I had been taking a counterfeit drug, so the results were short-lived while I took a course of other medications. As a result, I read reviews on the Internet and came to the conclusion that the drug is often counterfeited, the cost is not a penny, and it can be brewed normally. Now I’ve been taking the original drug for two months, I feel noticeably better, so the product really works.”
Doctor's review
Alexander Pichugin Doctor of the highest category,
“Artron triactive can be used regularly and seasonally; it has an effect on allergic manifestations and the causes that caused them. Using the drug for the first time, you can get rid of tearfulness, swelling, runny nose, nasal congestion, itching and rashes, cough and shortness of breath. The use of course methods of using this drug can ensure the elimination of allergic symptoms at the very peak of its season. In addition, from the use of the product you can expect the restoration of metabolic reactions, cleansing the body of poisons and toxins, increasing immune resistance, improving well-being, and increasing performance. This drug has participated in clinical-level studies and received the necessary certificates.”
Side effects and overdose of the drug
The drug Artron Triactiv is usually very well tolerated by patients of different age groups, but negative reactions also occur.
These include:
- Nausea and vomiting;
- Abdominal pain in the epigastric region;
- Headache;
- Increased fatigue;
- Digestive disorders;
- Sleep dysfunction;
- Skin reactions: itching, urticaria, erythema.
Nausea and vomiting
Stomach ache
Headache
Sleep disorders
Interaction with alcohol and drugs
The drug Artron Triactiv, the instructions for which are discussed below, is often used in the complex treatment of joint diseases. Additional agents that enhance the beneficial effects of the drug include glucocorticosteroids and non-steroidal anti-inflammatory drugs. It is worth noting that in such cases a dosage adjustment is required. An enhanced effect also occurs with simultaneous intake of vitamin formulations.
Artron Triactiv reduces the effectiveness of drugs from the penicillin group, and when taking tetracycline antibiotics, on the contrary, it enhances their absorption. The drug does not combine well with alcohol, so for better results, it is better to avoid alcoholic beverages during the treatment period. Artron Triactiv is also capable of increasing the toxic effects of narcotic anesthetics, which means avoiding taking the drug before elective operations.
