Artra® MSM is a combination product (a combination of four active components) that stimulates the restoration processes of cartilage tissue. The components of ARTRA® MSM help reduce inflammation and pain in the joints that accompany Osteoarthritis.
Osteoarthritis is one of the most common joint diseases, which is diagnosed in middle-aged people, athletes, and, more recently, young people. The destruction of cartilage tissue begins due to age-related changes, inflammation, injuries, and congenital pathologies. The disease causes restriction of joint mobility, causing discomfort, pain, and worsening the quality of life. Artra® MSM is a biologically active agent, the components of which are very effective for osteoarthritis of peripheral joints and osteochondrosis of the spine.
Component composition of Arthra and its pharmacological action
The instructions contain the following components of the medication:
- chondroitin;
- glucosamine;
- MCC;
- octadectanoic acid;
- magnesium stearate;
- calcium hydrogen phosphate;
- croscarmellose sodium.
The medicine is produced in tablets with a protective film coating, packaged in polyethylene jars. The packaging additionally contains instructions from the manufacturer.
Artra is a regulator of regenerative processes:
- Exogenous glucosamine - enhances the production of cartilage elements, protects them from various damage by chemicals. The element is used for the production of glycosaminoglycans in the body and has an anti-inflammatory spectrum of action.
- Chondroitin is a secondary nutrient for cartilage. With its help, the production of hyaluronan and proteiglycans is activated, and the aggressive effects of free radicals are suppressed. The ingredient acts as a stimulator of repair mechanisms in cartilage, reduces the activity of enzymes responsible for the breakdown of cartilage tissue. The element provides the necessary indicators of synovial viscosity.
If the patient has osteoarthritis and takes the drug, the symptoms of the pathology are relieved and the need for NSAID therapy is reduced.
Artra MSM Forte No. 30 tablet p.p.o.
Instructions for medical use of the drug ARTRA® MSM FORTE Trade name ARTRA® MSM FORTE International nonproprietary name No Dosage form Film-coated tablets Composition One tablet contains active ingredients: Chondroitin sulfate sodium 400 mg Glucosamine hydrochloride 500 mg Methylsulfonylmethane 300 mg Hyaluronic acid (sodium hyaluronate ) 10 mg excipients: microcrystalline cellulose, calcium hydrogen phosphate, stearic acid, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, shell composition: Opadry II orange (hypromellose, polydextrose, titanium dioxide (E171), magnesium hydrosilicate, maltodextrin, medium triglycerides , FD&C Yellow #6 (E110)). — SUBSTANCE Description Tablets are oval, biconvex, film-coated from light yellow-orange to dark orange. A specific odor is allowed. Pharmacotherapeutic group Other drugs for the treatment of diseases of the musculoskeletal system. ATC code M09AX Pharmacological properties Pharmacokinetics The bioavailability of glucosamine when taken orally is 25% (the “first pass” effect through the liver). Distributed in tissues: the highest concentrations are found in the liver, kidneys and articular cartilage. About 30% of the dose taken persists for a long time in bone and muscle tissue. Excreted primarily by the kidneys unchanged; partly by the intestines. The plasma concentration of chondroitin sulfate: when taken orally in a single dose of 0.8 g (or 2 times a day in a dose of 0.4 g) increases sharply over 24 hours. Absolute bioavailability is 12%. About 10% and 20% of the dose taken is absorbed in the form of high molecular weight and low molecular weight derivatives, respectively. Metabolized by desulfurization. Excreted in urine. T1/2 – 310 min. Experimental models have shown a certain bioavailability of hyaluronic acid when administered orally. Pharmacodynamics A combined drug, the effect of which is determined by the properties of the substances included in its composition. The components of the drug have the ability to inhibit the progression of osteoarthritis. ARTRA® MSM FORTE suppresses the destruction and stimulates the regeneration of cartilage tissue. The drug has an anti-inflammatory and analgesic effect. Improves blood flow in the subchondral bone. Reduces the need for non-steroidal anti-inflammatory drugs (NSAIDs). Glucosamine and chondroitin sulfate take part in the synthesis of connective tissue. Administration of exogenous glucosamine enhances the production of cartilage matrix and provides nonspecific protection against chemical damage to cartilage. Chondroitin sulfate also serves as an additional substrate for the formation of a healthy cartilage matrix. Stimulates the formation of hyaluronan, the synthesis of proteoglycans and collagen type II, and also protects hyaluronan from enzymatic breakdown (by suppressing the activity of hyaluronidase) and from the damaging effects of free radicals; maintains the viscosity of synovial fluid. Hyaluronic acid, a polysaccharide of the glycosaminoglycan group, is an important component of synovial fluid, determining its viscoelastic properties. It forms a covering layer on the entire inner surface that protects articular cartilage and synovium from mechanical damage, as well as from free radicals and inflammatory factors. Methylsulfonylmethane (MSM) is an organic sulfur-containing compound. It is a key metabolite of dimethyl sulfoxide (DMSO). Contains 34% natural sulfur. MSM is part of many endogenous proteins (including connective tissue proteins - collagen, elastin, keratin), hormones and other metabolically active compounds. MSM has anti-inflammatory and analgesic effects. Indications for use: osteoarthritis of peripheral joints, osteochondrosis of the spine. Method of administration and dosage: Orally. Adults: 1 tablet 2 times during the first three weeks; 1 tablet 1 time per day over the next weeks and months. Course of treatment for at least 3 months Side effects - possible allergic reactions to the components of the drug - epigastric pain, flatulence, diarrhea, constipation, nausea, vomiting Contraindications - increased individual sensitivity to the components of the drug - pregnancy and lactation - children and adolescents under 18 years of age Drug interactions Increases the absorption of tetracyclines, reduces the effect of semisynthetic penicillins. The drug is compatible with NSAIDs (non-steroidal anti-inflammatory drugs) and GCS (glucocorticosteroids). It is possible to enhance the effect of indirect anticoagulants, antiplatelet agents, and fibrinolytics. Special instructions Peculiarities of the drug's influence on the ability to drive a vehicle or operate potentially dangerous mechanisms. It has no effect. Overdose Symptoms: Cases of overdose are not known. If you take large amounts of the drug, side effects may increase. Treatment: activated carbon orally, gastric lavage, symptomatic treatment. Release form and packaging 30, 60 or 100 film-coated tablets in a polyethylene bottle with a screw cap made of the same material and a safety valve made of foil. A label is pasted onto the bottle, the bottle is covered with plastic wrap and, together with instructions for medical use in the state and Russian languages, it is placed in a cardboard pack. Storage conditions Store in a dry place, at a temperature of 10 - 30o C. Keep out of the reach of children! Shelf life 3 years Do not use after expiration date. Conditions for dispensing from pharmacies Without a prescription Manufacturer Unipharm, Inc., USA Registration certificate holder Unipharm, Inc., USA Address of the organization that accepts claims from consumers regarding product (product) quality in the territory of the Republic of Kazakhstan Representative office of Unipharm, Inc. (USA) in the Republic of Kazakhstan, Almaty, st. Nauryzbay Batyr 17, office 106 Phone number Fax number
Adverse reactions
Therapeutic procedures can cause non-standard responses in the body. Glucosamine, which is part of Arthra, causes dyspeptic disorders, active gas formation, discomfort in the epigastric region, diarrhea or constipation.
Secondary side effects include:
- attacks of dizziness;
- insomnia and drowsiness during the day;
- cephalgia, swelling in peripheral tissues;
- allergic reactions with redness of certain areas of the skin, dermatological rash, obsessive itching;
- accelerated heartbeat.
In some cases, chondroitin causes the development of individual intolerance to the drug. If non-standard symptoms appear, the patient should consult a doctor and describe in detail the changes in the condition and the main manifestations.
Restores cartilage tissue
During degenerative processes in the joints, cartilage is gradually destroyed. By using special means, you can not only slow down destructive processes, but also restore cartilage tissue that has undergone pathological changes. Glucosamine hydrochloride, which is involved in the synthesis of connective tissue, is responsible for the restoration of cartilage. When consuming the substance, the production of cartilage matrix increases, due to which cartilage restoration begins. Glucosamine hydrochloride also plays a nonspecific protective role in cases of cartilage damage due to exposure to chemicals that enter the body as a result of the use of other drugs.
Basics of Arthra Therapy
The instructions emphasize that in the first 21 days from the start of treatment, the drug is taken one tablet twice a day. Subsequent treatments are reduced to one tablet daily and can last several months.
The medication is used to treat patients over 15 years of age; the therapeutic effect obtained and the absorption rates of Arthra components are not related to the time of day or meals. Obtaining sustainable therapeutic results requires prolonged manipulation over one half year.
As a secondary drug to improve the condition of the musculoskeletal region, patients are prescribed Arthro-Active. The daily dosage of capsules varies from 4 to 6 pieces. Treatment lasts 2-4 weeks, followed by a two-week break and resumption of manipulations.
The abstract does not indicate any reported cases of accidental drug overdose. In theory, the drug can provoke adverse reactions when taking a large number of tablets. In this case, the patient will be prescribed symptomatic therapy.
Materials and methods
As part of the study, we assessed the effectiveness, tolerability and safety of the drug ARTRA MSM compared with the drug ARTRA in patients with knee OA when taken continuously for 4 months. The study included 100 sick men and women aged 45-75 years with significant (according to the criteria of the American College of Rheumatology) Kellgren-Lawrence stage II-III knee OA, with pain when walking >40 mm (according to VAS). Patients were examined monthly, the dynamics of the WOMAC index, the “get up and walk” test, the effectiveness of therapy according to the doctor and the patient, and quality of life were assessed using the EQ-5D questionnaire.
Patients were randomized into 2 groups. Group M ( n
=50) received ARTRA MSM according to the regimen: 2 tablets per day in the 1st month, then 1 tablet per day, group A (
n
=50) - ARTRA according to the same regimen. Group A included 47 women and 3 men, the right CS was conditionally accepted as the target in 70% of cases, the 2nd radiographic stage was observed in 88%. Concomitant diseases were present in 84% of patients. Group M consisted of 49 women and 1 man, the right CS was conditionally accepted as the target in 72% of cases, the 2nd radiographic stage was diagnosed in 78%, concomitant diseases in 88% of patients.
Before the start of therapy, both groups were comparable in age, duration of illness, body mass index and pain according to VAS (see table). All 100 patients completed the study. There were no deviations from the protocol. The calculation was carried out on a single population of recruited patients (50 in each group). The study recorded only one adverse event - constipation in a patient from group M, which was not the reason for interruption or cancellation of therapy.
Comparative characteristics of the examined patients before treatment* Note. * — average values are indicated. BMI - body mass index.
Manufacturer's instructions
The abstract draws attention to certain nuances:
- combination with anticoagulants and antiplatelet agents increases their spectrum of action;
- combination with tetracyclines – activates their absorption;
- taken together with penicillins reduces their effectiveness.
The drug should not be used simultaneously with glucocorticosteroids or anti-inflammatory drugs.
If during therapeutic procedures the patient experiences undesirable reactions from the digestive tract, then the dosage needs to be adjusted. The doctor should reduce the number of tablets. Lack of improvement requires discontinuation of the medication.
Restores motor functions of joints
To maintain joint mobility, synovial fluid must have certain viscoelastic properties, supported by sodium hyaluronate. Hyaluronic acid is produced by the body, but with joint diseases its amount is reduced. Taking Artra® MSM helps restore the normal balance of hyaluronic acid in the synovial fluid.
Hyaluronic acid promotes the formation of the covering layer, protects articular cartilage and synovial membranes from mechanical factors, free radicals, inflammation and swelling. As a result, there is a gradual restoration of motor functions of the joints.
Due to the content of ARTRA® MSM in all of the above components in the dosage required by the body, the product has a complex effect on pathological processes in the joints. Each component, effective individually, but in combination provides an enhanced effect, restoring cartilage tissue, providing an anti-inflammatory and analgesic effect.
When using Artra® MSM, you must follow the recommendations specified in the annotation. It is important to consider dosages depending on age and the nature of the problem.
Analogs
Non-standard manifestations of treatment require a revision of the prescribed regimen. The list of popular analogues of Arthra is presented:
- Arthrom MSM Forte, KONDROnova Tazan, Teraflex;
- Chondroflex, Chondroglyuksid, Adgelon;
- Alflutop, Biartrin, Gamma-plant;
- Discus Compositum, Synovial, Traumeel S;
- Rumalaya, Tselyu T, SINOART, Chondrotek Forte.
Substitutes are selected by the attending physician after undergoing a repeated laboratory diagnostic examination. The cost of analogues starts from 295 rubles, which allows you to choose an inexpensive and effective product.
