Indications for use
Dimexide has proven itself in the following diseases and problems:
- swelling of various origins;
- sprain;
- wounds with discharge of pus;
- burns;
- trophic ulcers;
- eczema;
- alopecia;
- acne;
- lymphostasis;
- thrombophlebitis.
Many doctors prescribe the remedy for diseases of the musculoskeletal system such as radiculitis, osteoarthritis, and arthritis. Dimexide is used in combination with other medications and medical procedures.
The product is used for gout, bruises, and to quickly break down traumatic infiltrates.
Dimexide has found application in gynecology. It is prescribed for cervical erosion, thrush, complications resulting from gynecological interventions and childbirth.
Due to its anti-inflammatory and bactericidal effect, the product is often used in cosmetology to combat wrinkles, acne, pimples and cellulite.
In dentistry, Dimexide is effective against inflammatory reactions in the maxillofacial part.
Dilution proportions
Pure Dimexide is not used for application to the lower back; it must be mixed with a solvent - distilled water. It is recommended to dilute the preparation for compresses on the lower back according to the ratio given in the table to obtain a solution of the required concentration.
| Required concentration, % | Volume fraction of the drug | Volume fraction of solvent – water |
| 10 | 1 | 9 |
| 20 | 1 | 4 |
| 30 | 3 | 7 |
| 40 | 2 | 3 |
| 50 | 1 | 1 |
| 90 | 9 | 1 |
Your doctor will tell you which concentration to choose for use . In most cases, obtaining a 50% solution is sufficient. To relieve severe pain, make a mixture with Novocaine - 3 parts of Dimexide to 5 parts of anesthetic.
The prepared solution cannot be stored for more than half a day. Then it becomes unusable. It is recommended to prepare it right before applying the compress.
How to take it correctly
Solution
The drug in the form of a solution is used externally. The product is washed over the affected areas of the body and used in the form of applications.
Dip a gauze cloth into the prepared solution and apply it to the damaged area for half an hour. Secure the top with a cloth. The procedure must be done 2-3 times a day for 12-14 days.
Gel
The gel can be used externally by patients over 12 years of age. Apply a thin layer of gel to the affected area. Carry out the procedure 1-3 times a day. The treatment course lasts from 12 to 14 days. If you need to resume the course, you should take a break for 10 days.
Dimexide 99% 100ml concentrate for preparing a solution for external use
pharmachologic effect
Anti-inflammatory agent for topical use.
Composition and release form Dimexide 99% 100ml concentrate for preparing a solution for external use
Concentrate:
- Active ingredient: dimethyl sulfoxide (dimexide) - 50 ml or 100 ml.
50 ml and 100 ml in orange glass bottles. The bottle along with instructions for use is placed in a cardboard pack.
Description of the dosage form
Colorless transparent liquid or colorless crystals, odorless or with a weak characteristic odor. Hygroscopic.
Directions for use and doses
Externally.
Dimethyl sulfoxide is produced in the form of a concentrate, from which, before use, an aqueous solution of the required concentration is prepared for application or irrigation (rinsing).
Moisten gauze pads in an aqueous solution of the required concentration and apply to the affected areas for 20-30 minutes. A plastic film and cotton or linen cloth are placed on top of the napkin. The recommended period for using applications is 10-15 days.
For the treatment of erysipelas and trophic ulcers - in the form of a 30-50% aqueous solution 2-3 times a day.
For eczema and streptoderma - compresses with a 40-90% aqueous solution.
For local anesthesia for pain syndromes - 25-50% aqueous solution in the form of compresses 2-3 times a day.
For facial skin and other highly sensitive areas, 10-20-30% aqueous solutions are used.
For children 12-18 years old, 20-30% aqueous solutions of dimethyl sulfoxide are used.
In skin plastic surgery, dressings with a 10-20% aqueous solution are used on transplanted skin auto- and homografts immediately after operations and in the subsequent days of the postoperative period until stable engraftment of the graft. A 5% solution of dimethyl sulfoxide in Ringer's solution is used as a preservative medium for storing skin homografts.
Purulent-necrotic and inflammatory foci and cavities are washed with less concentrated solutions (1-4%).
Preparation of an aqueous solution of dimethyl sulfoxide:
- Dimethyl sulfoxide content 10% - Number of parts of dimethyl sulfoxide / Number of parts of water 1/9;
- Dimethyl sulfoxide content 20% - Number of parts of dimethyl sulfoxide / Number of parts of water 1/4;
- Dimethyl sulfoxide content 25% - Number of parts of dimethyl sulfoxide / Number of parts of water 1/3;
- Dimethyl sulfoxide content 30% - Number of parts of dimethyl sulfoxide / Number of parts of water 3/7;
- Dimethyl sulfoxide content 40% - Number of parts of dimethyl sulfoxide / Number of parts of water 2/3;
- Dimethyl sulfoxide content 50% - Number of parts of dimethyl sulfoxide / Number of parts of water 1/1;
- Dimethyl sulfoxide content 90% - Number of parts of dimethyl sulfoxide / Number of parts of water 9/1.
Pharmacodynamics
Anti-inflammatory drug for external use, inactivates hydroxyl radicals, improves the course of metabolic processes in the site of inflammation. It also has local anesthetic, analgesic and antimicrobial effects; has moderate fibrinolytic activity.
Penetrates through the skin, mucous membranes, the membrane of microbial cells (increases their sensitivity to antibiotics) and other biological membranes, increases their permeability to drugs.
Pharmacokinetics
When dimethyl sulfoxide solution is applied to the skin, it is detected in the blood after 5 minutes. reaching maximum concentration after 4-6 hours, maintaining an almost unchanged level for 1.5-3 days. Dimethyl sulfoxide is excreted in urine and feces, both unchanged and in the form of dimethyl sulfone.
Indications for use Dimexide 99% 100ml concentrate for preparing a solution for external use
As part of complex therapy: diseases of the musculoskeletal system - rheumatoid arthritis, ankylosing spondylitis (Bekhterov's disease), deforming osteoarthritis (in the presence of damage to periarticular tissues), reactive synovitis, limited scleroderma, erythema nodosum, discoid lupus erythematosus, mycoses of the feet, keloid scars, thrombophlebitis, alopecia, eczema, streptoderma. erysipelas, bruises, sprains, traumatic infiltrates, purulent wounds, burns, radiculitis, trophic ulcers, acne, furunculosis. In skin plastic surgery - for preserving skin homografts.
Contraindications
Hypersensitivity to dimethyl sulfoxide, severe liver and/or renal failure, angina pectoris, severe atherosclerosis, glaucoma, cataracts, stroke, coma, myocardial infarction, pregnancy, breastfeeding, children under 12 years of age.
Application of Dimexide 99% 100ml concentrate for the preparation of a solution for external use during pregnancy and lactation
The use of the drug during pregnancy and breastfeeding is contraindicated.
special instructions
Some patients smell garlic in the air they breathe.
Before using the drug, it is necessary to test for tolerance to it. To do this, an aqueous solution of dimethyl sulfoxide of the required concentration is applied to the skin using a cotton swab soaked in it; the appearance of hyperemia and severe itching indicates hypersensitivity.
When stored at a temperature of 18 °C and below, crystallization of dimethyl sulfoxide occurs, which does not affect the quality of the drug. To melt the crystals, carefully heat the bottle in a water bath (water temperature no higher than 60 °C).
Impact on the ability to drive vehicles and operate machinery
Use of the drug in accordance with the instructions does not affect the ability to drive vehicles or operate moving mechanisms.
Overdose
Increased dose-dependent side effects are possible. In these cases, you should stop using dimethyl sulfoxide and rinse the damaged area. In case of accidental poisoning through the gastrointestinal tract, it is necessary to quickly rinse the stomach, remembering that dimethyl sulfoxide is quickly absorbed.
Treatment: symptomatic.
Side effects Dimexide 99% 100ml concentrate for preparing a solution for external use
Allergic reactions, contact dermatitis, erythematous rashes, dry skin, mild burning, itchy dermatitis, rarely - bronchospasm.
If side effects not described in the instructions occur, you should stop taking the drug and inform your doctor.
Drug interactions
Increases absorption and enhances the effect of ethanol (alcohol inhibits the elimination of the drug), insulin (with long-term use of the drug, the content of glucose in the blood plasma is monitored) and other drugs. Compatible with heparin, antibacterial agents, non-steroidal anti-inflammatory drugs. Increases the sensitivity of microorganisms to aminoglycoside and beta-lactam antibiotics; chloramphenicol, rifampicin, griseofulvin. Sensitizes the body to drugs for general anesthesia.
Contraindications
Dimexide should not be used in the following cases:
- impairment of kidney and liver function;
- stroke;
- sensitivity to constituent components;
- angina pectoris;
- cataract;
- coma;
- During pregnancy and breastfeeding.
When prescribing a drug, it is worth taking into account that it enhances the effect and negative impact of many other medications.
If a small amount of the active substance gets inside the body, it will provoke intestinal upset and spasms.
How to prepare a compress
A compress for back pain with Dimexide can be easily prepared at home.
For this:
- Prepare a solution of the required concentration in an enamel container; the water should be warmer than 18°C.
- Fold the gauze in several layers and soak in the resulting mixture, squeeze lightly.
- Apply to the area of the affected joint or spine.
- Cover with cling film, you can use plastic bags.
Keep the compress on the lower back for no more than an hour . The duration of treatment depends on the clinical picture, but it is not recommended to do more than ten compresses over ten days. In the future, you will need to consult a doctor about the effectiveness and tolerability of treatment.
Dimexide with Novocaine should be applied to the lower back no more than five times in a row for 5 days. For osteochondrosis, this combination will eliminate pain, muscle spasms in the area of the affected vertebrae, and relieve the process of inflammation in the intervertebral discs.
Medicine for children
The drug is approved for use by children over 12 years of age. It is prescribed for problems with the musculoskeletal system, ulcerative and purulent lesions of the skin, burns, eczema, and diseases of the upper respiratory tract.
The product is used for compresses, which provide excellent warmth, prevent the development of inflammatory processes, and eliminate an unpleasant cough. This method of treatment is suitable for sore throat and pharyngitis. It is best to do compresses before bed.
For bronchitis, this method allows you to improve blood circulation and improve the condition of the bronchi.
Medicinal properties
Dimexide is able to overcome biological membranes, therefore it quickly penetrates into the blood when applied externally to the lower back and is used for administering other drugs.
Having penetrated through all layers of the skin, the drug has the following effects for lower back pain:
- eliminates inflammatory foci;
- relieves high temperature, fever;
- helps prevent blood clots;
- eliminates bacteria and germs on the treated surface.
Thanks to these qualities, Dimexide for lower back pain eliminates not only the pain syndrome, but also its source - the source of inflammation. Apply as a compress. Effective for pinched nerves due to curvature of the spine or the formation of a spinal hernia in the lumbosacral, thoracic or cervical region.
The concentrations that Dimexide reaches in the blood are maintained for three days. It is eliminated from the body by the digestive tract and urinary system.
