"Hyalurom", "Ostenil", "Intraject" or "Noltrex"?

The most dangerous joint lesions are considered to be pathologies that affect cartilage. In this case, severe pain appears, the mobility of the joint worsens, which can become completely immobilized if therapeutic measures are not taken in time. To prevent such consequences, doctors prescribe a complex of medications, among which the drug Intraject is highly effective. It significantly alleviates the patient’s condition, relieves pain and inflammation, and helps restore the functioning of joints.

In what form is Intraject available?

The drug Intraject is available in the form:

• solution for injection into the joint cavity Intraject hyaluform synovial - colorless, transparent, thick liquid, comes in a 1 ml or 2 ml Luer-lock syringe, the concentration of the active component can be 1% and 1.8%;
• gel for external use Intraject T-Gel is a yellowish gel, packaged in 5 ml tubes.

According to the instructions for the drug, Intraject is used as part of complex therapy for arthrosis and arthritis, regardless of the stage and form of the disease. The effect of the drug is cumulative. More than half of the patients note a decrease in pain 10 weeks after the final injection into the cavity of the affected joint. The resulting effect of treatment lasts for 3-12 months.

"Ostenil"

"Ostenil" is a sterile solution of sodium hyaluronate, a highly purified biopolymer. No animal proteins are used in production, which completely eliminates allergic reactions to protein. A viscoelastic implant is indicated for degenerative and traumatic changes in the joints. It restores the lubricating, filtering and shock-absorbing properties of synovial fluid.

According to research results, the severity of pain after completing a course of Ostenil injections is reduced by an average of 55% after 3 months. The clinical effect develops after the first manipulation and persists for a period of at least six months. Is 55% enough to lead a normal lifestyle? The question is rhetorical.

Note!

The results of a study conducted by leading rheumatologists at the Institute of Rheumatology of the Russian Academy of Medical Sciences and several rheumatology centers are thought-provoking. A course of treatment with Ostenil consisting of three or five injections led to significant improvement only among 65-70% with gonarthrosis. Efficiency remained throughout the year in only 45-50% of subjects. The only good news is that the treatment did not produce serious adverse reactions, which means the drug is safe. How great its benefits are - the numbers speak for themselves.

And one more interesting point. In the instructions for the drug, the manufacturer recommends that doctors prescribe analgesics or anti-inflammatory drugs to patients during the first few days of treatment for osteoarthritis. It can be assumed that the pain syndrome after the introduction of a liquid endoprosthesis will be more noticeable than we would like.

Full course of treatment with Ostenil - 5 injections, or 5 weeks, or about 18,000 rubles

What effect does Intraject have?

The drug Intraject has the following therapeutic effect:

• replenishes the lack of synovial fluid;
• relieves inflammation and reduces pain;
• eliminates discomfort in the joint area;
• improves the mobility of the diseased joint;
• promotes restoration of deformed articular elements;
• prevents the degenerative process in joints;
• activates tissue regeneration.

Comparison of the characteristics of liquid endoprostheses "Hialurom", "Ostenil", "Intraject" and "Noltrex"

Composition of the drug Intraject

Intraject Hyaluform Synovial is a transparent viscous liquid that is intended to replace or replenish the lack of synovial fluid in the joint, lost as a result of pathologies of the musculoskeletal system. The consistency of the drug resembles a gel that is odorless. The main active ingredient of the solution is hyaluronic acid of a special form, obtained through bacterial fermentation. The composition for injection into the joint cavity does not contain animal proteins, which reduces the risk of developing allergic reactions in people with increased histamine production.

Intraject gel for external use contains:

• hyauloronic acid – provides lubrication and shock absorption of articular surfaces;
• glucosamine – stops the processes of tissue degeneration and joint destruction, helps reduce pain and produce synovial fluid;
• chondroitin - reduces the severity of the inflammatory process and pain, promotes the restoration of damaged joints, improves their performance, helps produce synovial fluid;
• methylsulfonylmethane – relieves inflammation, promotes the production of your own collagen;
• arnica extract – acts as an antiseptic, relieves inflammation and pain;
• comfrey extract – eliminates pain, reduces the severity of the inflammatory process; activates tissue regeneration;
• ginger extract – relieves inflammation, has an antioxidant effect, eliminates pain.

The gel is a chondroprotector and is included in the complex treatment of arthritis and arthrosis.

"Noltrex"

Noltrex is another endoprosthesis, a synovial fluid substitute, made in Russia. Of all the above-mentioned drugs, it is of synthetic origin, which gives it undeniable advantages. The components of the endoprosthesis, which do not include hyaluronic acid, as in other medications, are not broken down by enzymes in the human body, so the gel remains inside the joint for a long time and provides a long-lasting effect.

It is thanks to its synthetic nature that Noltrex is a completely hypoallergenic drug and is perfectly compatible with the tissues of the human body. Another feature of it is its record molecular weight, more than 10 million Da, thanks to which it is not removed from the joint for a very long time.

"Noltrex" is an inexpensive but very effective synthetic endoprosthesis with long-lasting action

How is Intraject used?

Injection of the solution into the joint cavity is prescribed by a doctor if there is no effect from conventional therapy. The solution must be administered by a specialist within the walls of a medical institution and under completely sterile conditions. The doctor must have special training to perform such procedures.

Before the injection, the injection site must be numbed, for example, with lidocaine. The solution for administration should be at room temperature. You can only give 1 injection per week. The duration of courses should not exceed 6 weeks, but when prescribing the dose and duration, the doctor takes into account the individual clinical picture. The drug should be administered strictly into the joint cavity - under no circumstances should it be administered inside the vessels or into the space outside the joint, joint capsules. If necessary, the course of injections is repeated, but you must wait at least 6 months.

Intraject T-Gel is used externally - applied to clean skin, then rubbed in until completely absorbed. This should be done twice a day: morning and evening. Using the gel, you can simultaneously treat several damaged joints.

A little about the price

Let's highlight:

• To keep osteoarthritis of the hip or knee under control with the help of the German drug “ Ostenil ” (costing only 3,500 rubles per injection!), you will have to fork out 10-18 thousand rubles every six months. That is, you will need from 20 to 36 thousand rubles , since the effect lasts on average only for 6-8 months.
• Treatment with Romanian “ Hyalurom ” will cost 15 thousand rubles per course - that is, about 30 thousand rubles per year .
• The Russian “ Intraject ” itself cannot be called cheap. A course of treatment with the drug costs 5,800 rubles. the injection will also cost at least 18 thousand rubles, and it will also probably have to be repeated twice a year, which means this amount is doubled - 36 thousand rubles.
• With Noltrex , which, according to some patients, costs not so little (from 3,100 rubles), you can save money. Even if the course consists of 4 injections, it will cost a little more than 12 thousand rubles . The effect will last for at least a year, meaning no additional investment is required.

Of course, it is “more prestigious” to treat arthrosis with an advanced German or popular Romanian drug. Many patients are skeptical about Russian developments, and this is still a tribute to the past. Today, some domestic medicines are not only not inferior to imported ones, but upon closer examination they even surpass them. See for yourself.

Are there any contraindications?

The drug in the form of an injection cannot be used for:

• high sensitivity to active components;
• bleeding of various origins;
• autoimmune diseases;
• infectious processes in articular or periarticular tissues;
• skin ailments in the area of ​​affected joints;
• infectious processes in the body.

Gel Intraject is not allowed to be used on wounds or abrasions on the skin, or in case of hypersensitivity to the constituent components. Also, the drug is not recommended for use in children under 18 years of age.

The use of Intraject during pregnancy and breastfeeding is possible only after the recommendations of the attending physician, who determines that the benefits of such treatment outweigh the potential risks.

What are the possible side effects?

Intraject is well tolerated by most patients. But there are still some possible side effects:

• skin redness;
• swelling;
• soreness;
• burning sensation;
• the appearance of intra-articular fluid;
• allergic reaction.

These symptoms are often short-lived and disappear on their own. But if they are observed a week after using the medicine, then you need to consult a doctor. It is very rare to experience septic arthritis, which may not even be related to the use of medication. In this case, the pain syndrome intensifies, body temperature rises, and local inflammation develops.

Features of application

The intraject is designed to eliminate pain and inflammation in the affected joint. But the disease itself cannot be cured with this remedy. Intraject is not able to strengthen bone tissue, improve blood microcirculation or restore cartilage. Only as part of complex therapy can the drug stop further destruction of the joint and promote tissue regeneration. The drug has an effective and prolonged effect, but can lead to a deterioration in the patient's condition at the beginning of treatment.

If Intraject hyaluform synovial is administered only by a specialist in a medical institution, then Intraject T-Gel can be used even at home, following the instructions for use.

Gel and liquid for intra-articular administration act at the local level and are not absorbed into the systemic circulation. This allows the medicine to be used for patients who have problems with the kidneys and liver.

Intraject should not be used together with drugs containing sodium hyaluronate and ammonium salts. Medical and surgical instruments should not be treated with solutions that contain these components.

If the packaging of the gel or solution for intra-articular administration is damaged, then the drug should not be used. Expired product must be disposed of. The drug should be stored in a place protected from sunlight and should not be frozen.

Advantages of Noltrex over the drugs Hyalurom, Ostenil and Intraject

• Due to its higher molecular weight, Noltrex lasts longer - up to two years (usually from a year to one and a half). It is impossible to get such a result from Hyalurom, Ostenil or Intraject.
• For a full course, sometimes 1-3 injections are enough, while preparations based on sodium hyaluronate must be administered at least 3 times, and in some cases 4-5.
• The cost of treating arthrosis of the knee, hip or elbow with Noltrex is significantly lower than with any other drug (about 12 thousand rubles for 4 injections, although two or three injections are often enough).

When choosing a drug for intra-articular injections, many are still guided by insignificant criteria. For some, the country of origin is a priority, for others, the cost of one injection is a priority. In fact, it is much more important to analyze the treatment regimen as a whole - with a future perspective, calculate the cost of treatment for the year, and study effectiveness statistics. The example of the comparison of popular liquid endoprostheses described above clearly shows the value of this particular approach.