Arthrocol gel instructions for use

Chondroitin-based ointment

In the form of an ointment, Artradol can be prescribed as an additional treatment. It is less effective, but still helps to cope with some symptoms of the pathology. Artradol ointment is applied externally. It is applied to the skin in the area of ​​the affected joint 1-2 times a day. The use of the product may cause adverse reactions such as burning, itching, and allergies. In such cases, you should stop using it and consult a doctor to eliminate side effects, as well as choose a different medicine. Ointment 5% can be an assistant in the treatment of pathologies of small and large joints, as well as the spine. It is contraindicated for young children, pregnant and lactating women.

Overdose

Since the level of ketoprofen, which penetrates the skin, in the blood plasma is low, an overdose is unlikely.

Main symptoms: irritation, erythema, itching.

Treatment: rinse the skin thoroughly under running water, stop using the gel and consult a doctor.

The development of systemic adverse reactions is possible when using the drug for a long time, in high doses or on large areas of the skin.

Accidental oral use of the gel can cause drowsiness, dizziness, nausea, vomiting, pain in the epigastric region, and taking ketoprofen in high doses can cause bradypnea, coma, convulsions, gastrointestinal bleeding, acute renal failure, increased or decreased blood pressure.

Treatment: symptomatic therapy with maintenance of vital body functions. Gastric lavage and activated charcoal may be helpful (the first dose should be given together with sorbitol), especially in the first 4 hours after an overdose or when taking a dose 5-10 times the recommended dose.

Pharmacological group

Pharmacodynamics

Diacerein is an inhibitor of the synthesis and activity of interleukin-1 (IL-1), which plays an important role in the development of inflammation, degradation and subsequent destruction of cartilage in osteoarthritis. Diacerein also helps slow down the formation of metalloproteinases (collagenases) involved in the processes of damage to cartilage tissue. In case of long-term use, the active substance stimulates the synthesis of proteoglycans without affecting the process of prostaglandin synthesis.

Pharmacokinetics

After oral administration, diacerein is rapidly absorbed from the gastrointestinal tract, completely deacetylated to rhein. When taking the drug simultaneously with food, bioavailability increases by 25%. The time to reach the maximum concentration of rhein (Cmax) in the blood plasma is 2.4 hours. The half-life is 4.25 hours.

The connection of rhein with albumin is about 100%. In the case of a single dose of the drug in a dose of 50 mg, Cmax is 3.15 mg/l, and with repeated use, Cmax increases due to the cumulation of the drug. About 20% of rhein is excreted unchanged by the kidneys, 60% as a glucuronide, and another 20% as sulfate.

Side effects

We were informed about local skin reactions, which could then go beyond the boundaries of the application of ketoprofen. In rare cases, there are episodes of more severe reactions, such as bullous or flextenulous eczema, which sometimes vary and become generalized in nature.

Other side effects of NPDD (hypersensitivity, damage to the side of the herbal tract and thyroid system) occur through the penetrating part of the active speech through the skin and, in particular, through the skin. and the applied gel, the flatness of the plot, the integrity of the skins, the dryness of the medicinal product and the curing of hermetic surfaces tongue

Ketoprofen can also cause attacks of bronchial asthma in patients with hypersensitivity to acetylsalicylic acid or the like.

Adverse reactions distributed across organ systems and frequency: very often (≥ 1/10), often (≥1/100, <1/10), infrequently (≥1/1000, <1/100), rarely (≥1 /10000, <1/1000), very rarely (<1/10000), the frequency is unknown (the frequency cannot be determined based on obvious data).

On the side of the immune system:

very rarely – hypersensitivity reactions, anaphylactic reactions.

On the side of the respiratory system, the thoracic organs and the mediastinum:

frequency unknown - bronchospasm, attacks of bronchial asthma.

On the side of the grass tract:

Very rarely - peptic rash, intestinal hemorrhage, diarrhea.

On the side of the skin and under the skin fabrics:

infrequently - hyperemia, itching, liver swelling, eczema, including bullous and flextenulosis, which tend to widen and become generalized; Rarely – pimples, pimples, photosensitivity reactions, bullous dermatitis (including exfoliative); very rarely – contact dermatitis, angioedema; frequency unknown – skin irritation, sagging skin, hyperhidrosis, purpura, erythema multiforme, skin necrosis, Stevens-Johnson syndrome.

On the side of the ranks and sechovidilnyh paths:

very rarely - increased nitric dysfunction or nitric deficiency (especially in patients with chronic nitric deficiency); unknown – interstitial nephritis.

Summer age patients are more vulnerable to the occurrence of adverse reactions in chronic NSAIDs.

Information about suspected adverse reactions

Information about suspected adverse reactions that occurred after drug registration is very important. This allows me to continuously monitor the balance of the measles/risks of the medicinal person. Health care professionals are asked to report any suspected adverse reactions through the national reporting system.

Analogues of the product

On the pharmacological market there are the following analogues of Arthrocol based on the active substance:

1. Ketoprofen - reduces inflammation, has analgesic, antipyretic and antiaggregation effects. Available in the form of capsules, gel, solution, suppositories and tablets. Recommended for inflammatory arthritis, arthrosis accompanied by pain, tendon and muscle injuries, as well as for short-term symptomatic treatment of acute pain due to lumbago and radiculitis. Can be used until the third trimester of pregnancy. Children under 14 years of age are not prescribed.
2. Valusal is a drug made on the basis of ketoprofen. It is used externally to relieve pain and inflammatory conditions of soft tissues. Contraindicated for children and adolescents (under 15 years of age).
3. Ultrafastin. Presented in the form of tablets and gel. Anesthetizes and relieves inflammation. It has the same indications and restrictions for use as Arthrocol.
4. Fastum gel - reduces inflammation in joints, tendons and muscles. Penetrates deeply into tissues, but does not have a negative effect on the body and is not addictive. Prescribed for acute and moderate pain in the lower back, pain caused by bruises, dislocated joints and sprained ligaments. If necessary, can be used during pregnancy.

The use of nonsteroidal anti-inflammatory drugs is an important component of complex therapy for inflammatory diseases of the musculoskeletal system and pain syndromes of various etiologies. Arthrocol is one of those drugs that help relieve inflammation and relieve pain, restore joint mobility and speed up recovery. To prevent the occurrence of side effects and the effectiveness of treatment, you must follow all the doctor’s recommendations regarding treatment with the drug.

Instructions for use, dosage and treatment regimen

Before using the gel, you must read the instructions and follow them during treatment. Before applying Arthrocol, the treated area of ​​skin should be washed with soap and dried. Then apply a thin layer of the product and rub it into the skin with massaging movements until completely absorbed. The larger the affected area, the more gel is required. The maximum daily dosage is 200 mg of gel.

After processing the epidermis, you should wash your hands with soap. The gel can be combined with other forms of Arthrocol (for example, with injections). Apply the product 1-2 times a day. The duration of the course depends on the degree of the disease, but should not exceed 10 days. After a while, therapy can be repeated.

Features of interaction with other drugs

When taking Arthrocol, you should take into account the peculiarities of its interaction with other medications. Thus, it enhances the effect of hypoglycemic and a number of anticonvulsants and reduces the effect of antihypertensive drugs and diuretics.

The medicine is not taken together with corticosteroids, salicylates, ethanol, since this greatly increases the likelihood of bleeding in the gastrointestinal tract. Similar consequences can be observed when the drug is used together with thrombolytics or antiplatelet agents.

With a high degree of caution, the medication is used in parallel with Aspirin and other NSAIDs, antidiabetic drugs, diuretics and some other drugs

Interactions

Since the concentration in the blood plasma is extremely low, the occurrence of symptoms of interaction with other drugs (similar to symptoms with systemic use) is possible only with frequent and prolonged use:

• with methotrexate, cardiac glycosides, lithium salts, cyclosporine - increased toxicity due to decreased secretion;
• with anticoagulants, acetylsalicylic acid or other NSAIDs, corticosteroids, oral hypoglycemic agents, phenytoin - enhancing the effect of the above-mentioned drugs;
• simultaneous use of the drug with other drugs in different topical forms (ointments, gels) containing ketoprofen or other NSAIDs is not recommended;
• with antihypertensive drugs, diuretics, mifepristone - a decrease in the effect of the above-mentioned drugs. At least 8 days should pass between the course of treatment with mifepristone and the start of therapy with ketoprofen.

Other recommendations for use

The gel is designed for external use. If the time for applying the drug is missed for some reason, the dose of the gel should be doubled during the next procedure. After application, wash your hands immediately to prevent the medication from getting into your eyes and mouth.

If negative reactions from the skin occur, treatment with Artrocol gel should be discontinued. This also includes skin reactions with the parallel use of products containing octocrylene. This substance is a component of many hygiene products:

1. lipsticks;
2. shampoos;
3. shaving and shower gels;
4. makeup removers;
5. anti-aging masks and creams;
6. hairsprays.

If any skin reaction occurs, therapy with Arthrocol Gel should be discontinued immediately. Do not apply the drug to open wounds, acne and other skin inflammations, to mucous membranes, avoid contact with eyes.

Photosensitivity is a fairly serious skin reaction that can develop if liniment-applied skin is exposed to ultraviolet rays (even on a foggy day or in a solarium).

To avoid such negative manifestations during the treatment period and in the next two weeks, you should not appear on the street with exposed areas of the body. For the same reason, you cannot visit the solarium during this period.

When applying the drug, it is advisable to use medical gloves to help avoid irritation of the skin of the hands.

External use of large amounts of liniment can have systemic effects, in particular bronchial asthma and hypersensitivity. To avoid these side effects, photosensitivity reactions and contact dermatitis, you should never exceed the dose recommended by the instructions for the drug. There are isolated cases of side effects from the kidneys.

If the patient, in addition to joint diseases, has pathologies of the cardiovascular system, kidneys and liver, treatment with Artrocol should be carried out with extreme caution. The condition of those patients who are taking lithium salts, anticoagulants and diuretics in parallel with Artrocol gel should be monitored no less carefully.

Since liniment contains ethyl alcohol, the medicine cannot be used in close proximity to an open flame.

Composition and release form

The drug is presented on the pharmacological market in the form of:

• solution;
• gel;
• candles

The active ingredient of Arthrocol is ketoprofen. The amount of its content in the solution is 100 mg. The product is placed in 2 ml ampoules. Its other components:

• sodium hydroxide;
• citric acid (monohydrate);
• arginine;
• water.

Arthrocol gel is produced in a 45 g tube, packed in a cardboard box. The concentration of the active substance in the drug is 2.5%. 100 gels contain 2.5 g of ketoprofen and the following components:

• ethanol;
• methyl parahydroxybenzoate;
• trolamine;
• carbomer 980;
• purified water.

Suppositories have a white or yellowish color and a smooth surface. Contains 100 mg of ketoprofen and solid fat.

Pharmacokinetic characteristics

According to the attached instructions, ketoprofen (the active component of the medication), after external application, is absorbed by the skin, and then penetrates into the focus of the inflammatory process and maintains the necessary therapeutic concentration in the tissues for a long time.

The absorption of this drug into the systemic circulation is minimal (about 5% of the dose used). In this case, absorption into the bloodstream occurs very slowly.

The concentration of the active substance of the drug (when using 50-150 mg of ketoprofen) in the blood after 7.5 hours is only 0.08-0.15 mcg/ml.

Important nuances when using the medicine

The drug in the form of a gel should not be applied to those areas of the skin that have undergone any pathological changes (for example, eczema), open wounds and infected areas.

Avoid contact of the composition with the eyes. If this happens, you should immediately rinse your eyes thoroughly with warm water. To avoid such situations, it is recommended to immediately wash your hands with soap. The use of gel with airtight dressings is not recommended.

Despite the fact that the plasma concentration of ketoprofen in the form of a gel is an order of magnitude lower than when taken orally, a ketoprofen-containing drug should be prescribed with caution to patients with a history of ulcerative lesions of the gastrointestinal tract, liver failure, renal failure and receiving coumarin anticoagulants. If even barely noticeable rashes appear on the skin after applying the gel, this is a reason to immediately stop treatment.

If even barely noticeable rashes appear on the skin after applying the gel, this is a reason to immediately stop treatment.

During therapy using Arthrocol (and for two weeks after its completion), the patient must avoid exposure to direct sunlight and refuse to visit the solarium.

If the use of the drug is prolonged, hematological parameters should be carefully monitored. This primarily applies to older patients.

You should not prescribe the medication to those patients who suffer from heart disease or arterial hypertension if they are accompanied by fluid retention in the body. If the need for medication outweighs, regular blood pressure monitoring is recommended.

The decision about the need to take Arthrocol should be made by the attending physician. Only he will be able to make the right decision regarding the required dosage and form of the medicinal substance. In addition, do not forget that self-medication can lead to a number of undesirable consequences.

Interactions with other medicinal drugs and other types of interactions

Systemic absorption of ketoprofen during local stagnation is very low, and there is no known interaction with other drugs, except for the onset of interaction was detected during stasis of oral forms of keto profen or other NSAIDs.

Methotrexate, lithium salts

With one-hour stagnation with ketoprofen, the excretion of methotrexate and salts decreases to a minimum. Concomitant treatment with methotrexate is not recommended due to a significant increase in toxicity.

Diuretics, antihypertensive agents

When taken for one hour with ketoprofen, the effect of diuretics and antihypertensive effects is weakened. Simultaneous administration of ketoprofen and diuretics or angiotensin converterase inhibitors also increases the risk of impaired thyroid function.

Acetylsalicylic acid, other drugs

With one-hour stagnation with ketoprofen, the effects and adverse reactions of NSAIDs will increase.

Probenecid

With one-hour stagnation with ketoprofen, the plasma clearance of ketoprofen and the level of its binding to proteins decreases.

Anticoagulants, antithrombotic agents, oral hypoglycemic agents (related compounds), anti-inflammatory agents (phenytoin)

When taken for one hour with ketoprofen, the effects of anticoagulants, antithrombotic agents, oral hypoglycemic agents (related drugs) and some anti-seizure drugs (phenytoin) will be effective.

Cardiac glycosides, cyclosporine

With one-hour stagnation with ketoprofen, the toxicity of glycosides and cyclosporine increases due to a decrease in their excretion.

Mifepristone

When taken for one hour with ketoprofen, the effects of mifepristone are weakened. Between the course of treatment with mifepristone and the beginning of therapy with ketoprofen, at least 8 days can pass.

It is known that topical ketoprofen does not interact with other medications, but in case of one-hour administration of coumarin anticoagulants, it is recommended to regularly monitor patients.

Treatment with Arthrocol gel during pregnancy and lactation

To study the drug, scientists conducted experiments on rodents. The results of these studies demonstrated that no embryotoxic or teratogenic effects were observed in animals. A slight embryotoxic effect was observed in experiments on rabbits. Doctors explain it as toxic to the rabbit.

Since the safety of ketoprofen in relation to pregnant women has not been supported by any studies (they simply were not conducted), doctors do not prescribe ketoprofen to expectant mothers, especially during the first and second trimester of pregnancy.

Ketoprofen and all other inhibitors of prostaglandin synthesis provoke toxic damage to the cardiac, pulmonary systems and kidneys of the fetus.

However, the instructions for use do not recommend treatment with the drug in the third trimester of pregnancy, since both the mother and the fetus may develop prolonged bleeding.

Ketoprofen products can be found in breast milk, and this factor does not depend on the dosage form (tablets, gel, rectal suppositories). For this reason, Arthrocol is not prescribed to women who are breastfeeding.

Features of good stagnation

Medical treatment should be administered with caution to patients with heart, liver or liver failure. There have been reports of isolated episodes of systemic adverse reactions associated with the severity of the disease.

Local use of large amounts of ketoprofen can lead to systemic effects such as hypersensitivity and bronchial asthma. Patients with bronchial asthma and those with chronic rhinitis, chronic sinusitis and/or nasal polyps have a higher risk of allergy to acetylsalicylic acid and/or NSAIDs, lower population levels.

Medical treatment should be taken with caution in patients with peptic virus infection, a history of inflammation of the intestines, cerebrovascular hemorrhage or hemorrhagic diathesis.

Summer age patients are sicker before adverse reactions appear in chronic NSAIDs.

Do not exceed the recommended strength of the gel and allow the medicinal effect to stagnate for three hours, as the risk of developing contact dermatitis and a photosensitivity reaction increases over time.

In addition, during the medical treatment period, the following precautionary steps must be followed:

• After applying the gel to the skin, wash your hands carefully;
• If any severe reactions occur, including those associated with concomitant stagnation of substances that require octocrylene (for cosmetic or hygienic reasons), it is necessary to immediately cause its stagnation ;
• do not apply the gel under the occlusive dressing;
• Do not apply the gel to the mucous membranes, areas around the eyes or internally;
• do not apply the gel to the anal or genital area and apply it together with other local treatments on the same areas of the skin;
• The gel should not be applied to open areas, so as not to remove alcohol;
• If the hour of application of the gel is missed, the dose should not be adjusted if the patient has been prescribed a dose;
• Since the medical procedure must be preserved for a long time, then surgical gloves should be worn.

Excessive exposure to sunlight (like on a foggy day) or exposure to UV radiation on the skin in a solarium during a period of temporary exposure to ketoprofen may cause potentially serious skin reactions (photosensitivity). i). To understand the development of the photosensitivity reaction of the skin, it is recommended to protect the parts of the skin on which the gel is applied with clothing, during an hour of bathing and for 2 days after drying. Also, do not remove the solarium during the bathing period and for 2 days after drying.

It is recommended to remove methyl parahydroxybenzoate (E 218), which may cause allergic reactions (possibly enhanced).

Suspension during pregnancy or breastfeeding.

I and II trimester of gestation

No studies have been carried out to monitor the safety of ketoprofen administration to vaginal women; in the 1st and 2nd trimester of pregnancy, medicinal administration is unique.

III trimester of gestation

All inhibitors of prostaglandin synthesis, including ketoprofen, cause toxic effects on the cardiopulmonary system in the fetus and are not harmful. For example, both the mother and the child may experience bleeding. The doctor has diagnosed the disease; the use of medication is contraindicated in the third trimester of pregnancy.

Breast bath period

It is unknown whether ketoprofen passes into breast milk. The medicinal dose should not stagnate during the breastfeeding period.

This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.

There is no evidence for the infusion of topical ketoprofen into the construction of keruvate by motor transport or other mechanisms.

Pharmacodynamics and pharmacokinetics

After oral administration, diacerein is rapidly absorbed from the gastrointestinal tract and is completely deacetylated to rhein. Simultaneous administration of the drug with food increases bioavailability by 25%. Cmax of rhein in plasma is achieved after 144 minutes. T1/2 from plasma is 255 min. The connection of rhein with albumin is almost 100%. With a single dose of 50 mg, Cmax reaches 3.15 mg/l.

Absorption is fast, bioavailability is 90%. The maximum concentration in the blood is achieved within 2.4-4 hours. The degree of binding to proteins, mainly albumins, is 99%. The half-life is about 2 hours.

Ketoprofen quickly penetrates the blood-brain barrier into the synovial fluid. The concentration of ketoprofen in the synovial fluid is lower than in the blood, but remains there for a longer time, which determines the long-term effect of the drug.

Ketoprofen is extensively metabolized in the liver using microsomal enzymes. It is excreted from the body mainly in the form of a conjugate with glucuronic acid, mainly in the urine; a small part of the drug is excreted in the feces.

Gel Arthrocol

Contraindicated

• Such as hypersensitivity reactions, such as symptoms of bronchial asthma, allergic rhinitis, which occur when taken with dexketoprofen, ketoprofen, fenofibrate, tiaprofenic acid, acetylsalicylic acid, or others NPZZ.
• Sensitivity to other components of the drug has been increased.
• Any history of photosensitivity reactions.
• A history of severe manifestations of allergies when taking dexketoprofen, ketoprofen, tiaprofenic acid, fenofibrate, ultraviolet (UV) blockers or perfumes.
• Infusion of sleepy changes (with a splash of pink light) or UV exposure in a solarium under an hour of treatment with a medicinal method and for 2 days after the end of the stagnation.
• Suspension in the presence of pathological changes in the skin, such as weeping dermatoses, chapped skin, dryness, skin injuries, rashes, eczema or acne, or infectious processes of the skin and open wounds.
• III trimester of gestation.

Features of application

According to the instructions for use of the Arthrocin gel, it helps to quickly eliminate pain, reduce swelling and swelling in the affected joints, and also stimulate the production of synovial fluid. This product is applied to the skin in the area of ​​the affected joint in a thin layer, and then rubbed in with light massaging movements. The gel is applied 2-3 times a day, for 3-5 days, then you need to take a break for 2-3 days. Thus, treatment is carried out throughout the entire recovery period. The course of therapy is approximately 1-4 months, it all depends on the severity of the pathological process

It is important to remember that there should be no abrasions, wounds, scratches or other damage to the skin at the site where the gel is applied.

Before purchasing this product, you need to consult with your doctor, study the instructions for use of the Arthrocin gel and reviews. The price of this product is quite reasonable, so many patients prefer to use it for therapy.

Pharmacological properties

Non-steroidal anti-inflammatory drugs. Propionic acid derivatives. Ketoprofen. ATX code M01A E03.

Ketoprofen is an NSAID that has analgesic, anti-inflammatory and antipyretic effects.

During inflammation, ketoprofen inhibits the synthesis of prostaglandins and leukotrienes, inhibiting the activity of cyclooxygenase and partially lipoxygenase, also inhibits the synthesis of bradykinin and stabilizes lysosomal membranes.

It has a central and peripheral analgesic effect and eliminates the symptoms of inflammatory and degenerative diseases of the musculoskeletal system.

Pharmacokinetics.

Absorption. The average concentration of ketoprofen in blood plasma is 26.4-5.4 mcg/ml 4-5 minutes after infusion or administration. The bioavailability of ketoprofen is 90%.

In most patients, after administration, ketoprofen is detected in the blood within 15 minutes, and the maximum concentration in the blood plasma is reached after 2:00. The bioavailability of ketoprofen in the form of an injection solution is linearly dependent on the dose of the drug.

Distribution. Protein binding - 99%. Volume of distribution - 0.1-0.2 l / kg. Ketoprofen penetrates into the synovial fluid. 3:00 after administration of 100 mg of ketoprofen, its concentration in the blood plasma is about 3 μg/ml, and the concentration in the synovial fluid is 1.5 μg/ml.

Although the concentration of ketoprofen in the synovial fluid is slightly lower than in the blood plasma, it is stable (after 9:00 the concentration of ketoprofen in the blood plasma is 0.3 μg / ml, and in the synovial fluid - 0.8 μg / ml), therefore the pain syndrome and joint stiffness is reduced for a long time.

A stable concentration of ketoprofen in the blood plasma is achieved within 24 hours after administration. In elderly patients, a stable concentration of ketoprofen in the blood plasma is achieved after 8.7 hours and is 6.3 mcg/ml. There is no accumulation of ketoprofen in tissues.

Metabolism and excretion. Ketoprofen is extensively metabolized in the liver using microsomal enzymes. It is excreted from the body in the form of a conjugate with glucuronic acid. The half-life is 2:00. Up to 80% of the administered dose of ketoprofen is excreted in the urine, usually (more than 90%) in the form of glucuronide, about 10% in feces.

In patients with impaired renal function, the elimination of ketoprofen is slow, the half-life increases by 1:00. In patients with impaired liver function, ketoprofen may accumulate in tissues. In elderly patients, the metabolism and excretion of ketoprofen slow down, but this is of clinical significance only in cases of impaired renal function.

Overdose

If the fragments of rhubarb ketoprofen penetrate through the skin, the blood plasma level is low, then overdose is less likely. Main symptoms: teasing, erythema, itching.

Cleaning: carefully wash the skin under running water, soak in the gel and apply to the doctor.

The development of systemic adverse reactions is possible when the drug is used for a long time, in high doses or on large areas of the skin. Oral ingestion of the gel can cause drowsiness, confusion, fatigue, vomiting, pain in the epigastric region, and taking high doses of ketoprofen can cause bradypnoe, coma, intestinal hemorrhage, gastric insufficiency, advancement or reduction of arterial pressure.

Treatment: symptomatic therapy to improve vital vital functions of the body. It may be necessary to rinse the mucus and take active vugill (the first dose is given at once with sorbitol), especially in the first 4 years after an overdose or when taking a dose that is 5-10 times higher than the recommendation.

This is an interesting opinion from the public

We surveyed patients of some clinics, and this is how they respond to the drug Artrocol.

I have been taking Arthrocol for quite a long time because I suffer from arthrosis. I can say that this is an excellent NSAID. One cannot count on a complete cure, especially at my age. But the drug relieves pain and restores joint function perfectly.

If you supplement your intake with physical therapy, massage and proper nutrition, you can feel quite acceptable. I know this from myself, and for those who doubt whether they should try the medicine, I strongly recommend that they cast all doubts aside.

Anna Belyaeva, 67 years old

I developed arthrosis of the joints due to long-term volleyball training. I tried many different remedies - if relief came, it was insignificant and did not last long.

Now the doctor prescribed Arthrocol and said that if it doesn’t help, he will insist on examination in a hospital. I don't think this will be needed. After the first week of taking the medicine, the pain began to go away and the swelling decreased. So I'm full of optimism.

Svetlana Vladimirovna, 59 years old

I am a smoker with forty years of experience. From time to time I try to quit, and against this background my joints begin to ache very much. Experts insist that this is due to withdrawal syndrome. A doctor friend recommended taking Artrocol.

And although I initially doubted the validity of its prescription - I don’t have arthrosis, I bought the drug at the pharmacy. Surprisingly, it worked. Now I can at least sleep normally, and the nicotine hunger is relieved with the help of a patch.

Victor Mitrofanov, 55 years old

A few months ago I was diagnosed with osteochondrosis, which developed during pregnancy.

The doctor prescribed Arthrocol. The drug is simply excellent, the pain went away almost completely when I started taking it. I highly recommend it to everyone.

Albina Beloborodova, 33 years old

Additionally

should not be applied to areas of skin with pathological changes such as eczema or acne; or infected skin areas or open wounds. Avoid getting the gel on mucous membranes or eyes. After applying the gel, you should immediately wash your hands.

The drug is not recommended for use with occlusive (airtight) dressings.

Despite the fact that the plasma concentration after using ketoprofen in gel form is much lower than when taken orally, caution must be exercised when prescribing the drug to patients with a history of gastrointestinal ulcers, renal or liver failure, and those receiving coumarin anticoagulants. The appearance of skin rashes after applying the drug is grounds for stopping its use.

During treatment and for 2 weeks after treatment, direct sunlight, including solariums, should be avoided.

simultaneously with acetylsalicylic acid and other NSAIDs, lithium preparations, antihypertensive agents, diuretics, methotrexate, antidiabetic agents and anticoagulants.

With long-term use of ketoprofen, regular monitoring of hematological parameters, liver and kidney function parameters is required, especially in elderly patients.

Ketoprofen should be prescribed with caution to patients with arterial hypertension and heart disease accompanied by fluid retention in the body; blood pressure monitoring is recommended. When prescribing ketoprofen, caution should be exercised in patients with a history of gastric, duodenal ulcers or gastrointestinal bleeding, impaired renal or hepatic function

When prescribing ketoprofen, caution should be exercised in patients with a history of gastric, duodenal ulcers or gastrointestinal bleeding, impaired renal or hepatic function. Ketoprofen, like other NSAIDs, can mask the symptoms of an infectious disease

Ketoprofen, like other NSAIDs, can mask the symptoms of an infectious disease.

Patients who notice any side effects from the central nervous system should refrain from driving a car or using machinery.

Contraindications

Known hypersensitivity reactions (for example, symptoms of asthma, allergic rhinitis or urticaria that occurred when using ketoprofen, fenofibrate, tiaprofenic acid, acetylsalicylic acid or other NSAIDs); hypersensitivity to any of the excipients; a history of skin allergies when using ketoprofen, fenofibrate, tiaprofenic acid, ultraviolet blockers or perfumes; history of photosensitivity; exposure to sunlight, including indirect sunlight and ultraviolet irradiation in a solarium, during the entire period of treatment and another 2 weeks after cessation of therapy; damage to the integrity of the skin (wound, rash, eczema, trauma, skin infections).

What is the drug Artrocol gel intended for?

Indications for the use of the gel in question are the following conditions:

• myalgia of non-rheumatic and rheumatic origin;
• diseases of the musculoskeletal system (including rheumatoid arthritis, articular syndrome during exacerbation of gout, ankylosing spondylitis, psoriatic arthritis, osteochondrosis, osteoarthritis of various localizations, inflammatory damage to tendons, ligaments, sciatica, bursitis or lumbago);
• as part of complex treatment for inflammatory pathologies of the veins (for example, phlebitis, periphlebitis), lymph nodes or lymphatic vessels (for example, lymphangitis, superficial lymphadenitis);
• post-traumatic inflammation of the musculoskeletal system and soft tissues (including symptomatic treatment of uncomplicated injuries, including dislocations, sports injuries, sprains or ruptures of tendons and ligaments, bruises, post-traumatic pain).

Possible side effects

What negative effects can the drug “Arthrocol” (gel) cause? The instructions talk about the following negative effects:

• bronchospasm, angioedema;
• asthmatic attacks, anaphylactic reactions, including shock;
• redness, itching, hives, burning and swelling of the skin;
• bullous and phlyctenulous eczema, which can spread to other areas and also become generalized;
• photosensitivity, bullous or contact dermatitis;
• nausea, Stevens-Johnson syndrome, vomiting;
• bleeding, stomach ulcer, diarrhea, heartburn, constipation;
• impaired renal function, exacerbation of chronic renal failure, interstitial nephritis and the development of renal failure.

It should also be noted that when using Arthrocol gel, other adverse reactions from the digestive system and urinary system may occur. The intensity of such effects depends on the amount of the drug used, as well as the penetrating ability of its active ingredient, the size of the treated area, the duration of the therapeutic course and the condition of the skin.

It should also be said that older people are most susceptible to side effects when treated with NSAIDs.

Note!

The description of the drug Artrocol gel 25 mg/g tube 45 g on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.