Comparison of the effectiveness of Alflutop and Artradol
Artradol is more effective than Alflutop - this means that the ability of the drug substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Artradol is more pronounced, then with Alflutop it is impossible to achieve this effect even in large doses.
Also, the speed of therapy is an indicator of the speed of therapeutic action; Artradol and Alflutop are also different, as is bioavailability - the amount of a drug substance reaching the place of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Artradol
chondroitin sulfate as a therapeutic component . This is the main substance of proteoglycans, which in combination with collagen form the cartilage matrix.
The drug has a chondroprotective effect ; it suppresses the activity of enzymes that destroy articular cartilage.
The medicine relieves pain and inflammation, promotes the restoration of cartilage tissue, normalizes the production of joint fluid, resulting in improved joint mobility. It stimulates the biosynthesis of proteoglycans by chondrocytes and has a positive effect on the exchange of calcium and phosphorus in cartilage tissue.
Chondroitin sulfate is structurally similar to heparin and may therefore potentially inhibit the formation of fibrin clots in the synovium.
The drug slows down bone resorption and reduces calcium loss, accelerating the restoration of bone tissue. After completion of therapy, the therapeutic effect of the medication persists for a long time.
The drug is prescribed for degenerative-dystrophic pathologies of the joints and spinal column, such as intervertebral osteochondrosis, primary arthrosis and osteoarthrosis, which mainly affects large joints.
Comparison of safety of Alflutop and Artradol
The safety of a drug includes many factors.
At the same time, in Alflutop it is quite similar to Artradol. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Alflutop, as well as Artradol, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Alflutop does not have any risks when used, just like Artradol.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Alflutop and Artradol.
Differences
There are the following differences between the drugs Artradol and Alflutop:
| Artradol | Alflutop | |
| Release form | The medicine is available in capsules for oral administration and lyophilisate, from which, when diluted, a solution for intramuscular administration is obtained. | The drug is available in an injection solution that can be administered intramuscularly or intraarticularly. |
| Manufacturer country | The medicine is produced in Russia. | The drug is produced in Romania. |
| Use in pediatrics | Capsules are allowed for patients over 15 years of age; injections can only be given to patients over 18 years of age. | The medication is intended for adults only. |
| Use during pregnancy and breastfeeding | Capsules are contraindicated in patients expecting a baby and breastfeeding; injections can be given to them with caution. | The medicine is not recommended for women who are pregnant or who are breastfeeding. |
| Contraindications | The medicine should be used with caution in patients with thrombophlebitis, bleeding and a predisposition to it. | It is not advisable to use the drug for people with intolerance to sea fish, as the risk of an allergic reaction increases in such patients. |
| Sales rules | Capsules are available without a doctor's prescription; lyophilisate can only be purchased with a prescription. | Ampoules with a solution of the drug can be purchased with a doctor's prescription. |
| Drug interactions | The medicine enhances the effect of indirect anticoagulants, thrombolytics, and antiplatelet agents, so if drugs of this group are prescribed during therapy, blood clotting indicators must be monitored more often. | There are no registered drug interactions between Alflutop and other medications. |
| Storage rules | The lyophilisate should be stored in a dark place. The drug should be kept away from children. Regardless of the release form, the medication does not lose its therapeutic properties at temperatures up to 25 degrees. | Injections should be stored in a dark place, out of reach of children, at a temperature of 15-25 degrees. |
| Adverse reactions | Taking capsules can cause nausea, vomiting, and allergies, which are manifested by urticaria, itching, and erythema. Injections can also provoke allergic reactions; in addition, they can cause hemorrhage at the injection site. | Treatment with the drug can cause anaphylactic reactions, itchy dermatitis, redness of the skin, a burning sensation at the injection site, and muscle pain that quickly passes. When the medication is injected into the joint, increased pain may occur. |
| Overdose | When taking capsules in dosages higher than therapeutic ones, undesirable reactions from the digestive tract, such as nausea, vomiting, and stomach upset, may occur. If you take capsules for a long time in daily dosages of more than 3 g, this can cause hemorrhagic rashes. The antidote for drug poisoning is unknown, so the victim is prescribed symptomatic therapy. | If therapeutic dosages are exceeded, increased side effects from the drug may occur. There is no known antidote for overdose, so symptomatic treatment is indicated. |
Comparison of addiction between Alflutop and Artradol
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “o syndrome” in Alflutop is quite similar to the similar values in Artradol. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Alflutop has a fairly low value of the “syndrome”, however, the same as Artradol.
Instructions for use ALFLUTOP®
During clinical studies, the distribution in the body of the active substance of the bioactive concentrate of small sea fish - the active substance of the drug Alflutop® - solution for intramuscular and intra-articular administration was studied.
131I for tyrosine and 99Tc for glycopyranose were used as isotopic labels. The isotope-labeled concentrate was administered to Wistar rats. Activity was measured for the following organs and organ systems: blood, lungs, kidneys, liver, spleen, joints, muscles, skin and fur, and adipose tissue.
The distributed active substance was recorded in all organs and systems of the body. A study of the distribution of the labeled bioactive concentrate of small marine fish (131I for tyrosine and 99Tc for glycopyranose) after intra-articular administration to animals confirmed the selective accumulation of the active substance in the joints throughout the entire period.
Preclinical safety data
A toxicity study after a single dose, carried out on mice and rats, males and females, by intraperitoneal administration, respectively intramuscular in rats and subcutaneous in mice, showed that Alflutop®, a solution for intramuscular and intraarticular administration, is not toxic.
Repeated dose toxicity: intramuscular administration in rats for 14 days of doses from DT x 5 to DT x 20 (DT - temporary dose) (subacute toxicity), respectively, for 3 months (chronic toxicity) did not significantly change the weight gain of animals, daily feed consumption, hematological and biochemical constants, mass of major organs, morphological and macro- and microscopic appearance, compared with control groups.
Intramuscular administration in rabbits for 4 months doses in DT x 1; DT x 5; DT x 10 did not lead to the appearance of toxic changes (chemical, hematological, biochemical, anatomical pathological).
Sensitizing potential: the results of tests on mice demonstrated that Alflutop®, a solution for intramuscular and intra-articular administration, is not a potential allergen.
Studies on the effect of the drug Alflutop® - a solution for intramuscular and intra-articular administration on the reproductive process, conducted on two generations of rabbits and rats, showed that the drug does not have an embryotoxic or teratogenic effect, and does not affect the reproductive process in placental animals.
Testing of mutagenic potential using the Ames test, the chromosomal aberration test in mouse bone marrow and the micronucleus test led to the conclusion that Alflutop®, a solution for intramuscular and intra-articular administration, does not have mutagenic properties and can be used in human therapy.
Comparison of side effects of Alflutop and Artradol
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Alflutop has almost the same level of adverse events as Artradol. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Alflutop are similar to Artradol: how quickly the body recovers after taking it and whether it recovers at all.
Alflutop
Alflutop is a chondroprotector . The therapeutic effect of the drug is explained by a bioactive concentrate from small sea fish . It contains aminocarboxylic acids, peptides, sodium, potassium, calcium, magnesium, iron, copper, zinc, glycosaminoglycans (chondroitin sulfate).
The medicine prevents the destruction of macromolecular structures of normal tissues. It restores interstitial and cartilage tissue. This explains the pain-relieving effect of the medication.
The drug inhibits the activity of hyaluronidase and normalizes the formation of hyaluronic acid, it stops the inflammatory process and restores the structure of cartilage. The medicine is prescribed for spondylosis, osteochondrosis, primary and secondary osteoarthritis of various locations.
What to choose?
It is impossible to say unequivocally what is better: Artradol or Alflutop. These drugs should be prescribed by a doctor depending on the diagnosis, the age of the patient, the presence of contraindications to the start of treatment and its tolerability.
If there are pathologies of the locomotor system in children over 15 years of age, they are recommended to take Artradol capsules, and pregnant and lactating women can be given injections. If the patient has a predisposition to bleeding, thrombophlebitis, or has been prescribed drugs that affect blood clotting, then it is better to be treated with Alflutop.
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