Sarcoma of the hip: diagnosis and treatment


Sarcoma is a malignant tumor that is formed by mutated connective tissue cells. It can occur almost anywhere in the body, including large joints.

Our expert in this field:

Sergeev Pyotr Sergeevich

Oncologist, surgeon, chemotherapist, Ph.D. Member of the international society of surgical oncologists EESG

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One such joint, the hip joint, connects the femur and pelvis. The head of the femur and the acetabulum of the pelvic bone are covered with smooth hyaline cartilage, which allows for gliding. The joint cavity is filled with fluid, which acts as a lubricant; it is enclosed in a synovial bursa.

Accordingly, there are three main types of sarcoma - growing from bone, from cartilage and from the synovial bursa. The first is Ewing's sarcoma, the second is chondrosarcoma, and the third is synovial sarcoma.

Other tumors can also form in the hip joint area - fibrosarcoma, osteosarcoma, fibrous histiocytoma. They vary in degree of malignancy, but in general, sarcomas are among the most aggressive tumors; they grow rapidly, increasing in size, and actively metastasize.

Like many other oncological diseases, sarcomas of the hip joint often appear too late, in the third and fourth stages, when there are already metastases not only in regional lymph nodes, but also in distant organs - lungs, intestines, liver, fallopian tubes, ovaries, stomach. This significantly complicates treatment and explains the negative prognosis in most cases.

The five-year survival rate at a late stage, with large sarcoma sizes, is usually no more than 17–25%. Meanwhile, treatment carried out at the middle stage gives an indicator of up to 70%, and at the initial stage - up to 80–90%.

Of course, a lot depends on the type of sarcoma and the individual characteristics of the body. The worst prognosis is for Ewing's sarcoma, which corresponds to the fourth degree of malignancy. The prognosis for chondrosarcoma is significantly better.

High results in the treatment of hip sarcomas at the international clinic Medica24 are achieved thanks to an interdisciplinary approach. Several specialists are involved in determining patient management tactics: oncologists-surgeons, orthopedic oncologists, and chemotherapists.

This helps to develop an optimal treatment program and achieve the highest possible effectiveness.

In many cases, this makes it possible to achieve the goal by using organ-saving, gentle techniques, while completely removing the tumor, its metastases and minimizing the risk of relapses.

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Hip cancer

Hip cancer is a malignant lesion of bone tissue resulting from genetic mutations of healthy cells. A cancerous tumor in the femoral region mainly occurs as an osteogenic sarcoma.

The tumor is characterized by extremely aggressive growth and early formation of metastases.

Sarcoma of the hip is diagnosed in almost all age categories, but most often occurs in young males.

Causes

The exact cause of hip sarcoma has not been established to date. Scientists have identified cancer risk factors:

Rapid physiological growth of bone tissue:

Statistically, children with hip cancer have increased growth rates. Bone damage usually occurs in areas of the most active growth of skeletal tissue.

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Very often, the patient associates the formation of a tumor in the hip bone with a previous injury to the lower extremity. These complaints force the doctor to prescribe an x-ray examination.

Irradiation of the body with highly active x-rays is a direct stimulator of bone sarcoma.

  • Paget's disease.
  • Benign tumors of bone tissue.
  • Genetic predisposition.
  • Leg bone cancer.

Symptoms of hip cancer

The main symptom of the disease is pain in the affected area. Dull and constant pain tends to gradually increase in intensity. A characteristic feature of osteogenic sarcoma is night pain.

During the development of the malignant process, the patient experiences soft tissue changes in the form of an increase in volume and the formation of edema. The result of such symptoms is impaired motor function of the lower limb.

Hip cancer predominantly metastasizes at an early stage. Thus, 80% of patients at the time of diagnosis have micrometastases in the lung tissue, which can only be detected using computed tomography. Due to the fact that the skeletal system has a poorly developed network of lymphoid tissues, the spread of cancer cells occurs through the hematogenous route.

Treatment of hip sarcoma

Therapy for hip cancer consists of the following sequential stages:

  1. Preoperative preparation of the patient.

Treatment of the patient begins with a course of chemotherapy, which consists of taking a complex of cytostatic drugs. The goal of this method is to reduce and stabilize the volume of pathological tissue to ensure a favorable outcome of surgery. Chemotherapy also prevents the formation of metastases in distant organs and systems.

The diagnosis of osteoid sarcoma requires mandatory surgical excision of the tumor along with adjacent healthy tissue and regional lymph nodes.

Until recently, the operation was carried out according to the radical type with the removal of the lower limb. Modern research proves the high effectiveness of gentle surgical technology.

Even the presence of large metastases in the body is not considered a reason to cancel organ-conserving surgery.

  1. Postoperative period.

After surgery, a second course of chemotherapy is usually given to destroy remaining cancer cells and prevent relapse of the disease.

This pathology is not subject to such a standard method of therapy as ionizing radiation, due to the low sensitivity of osteosarcoma tissue to highly active x-ray irradiation. The use of radiation rays is justified only if surgery is not possible.

Prognosis and survival rate for hip bone cancer

Early diagnosis and timely treatment using modern therapeutic techniques determine a favorable outcome of surgical intervention. In recent years, the chances of survival of patients with metastases in the human respiratory system have increased significantly.

The effectiveness of surgery for hip cancer can be assessed by five-year survival rates, which are:

  • Localized form of sarcoma – 70%.
  • Tumor sensitive to chemotherapy drugs – 80-90%.

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More about the disease

Hip cancer is a fairly rare pathology; it consists of the formation of cancer cells, and then a tumor in the bone tissue.

There are different types of malignant tumors in the pelvis and hip, they differ in symptoms, location, and treatment. The most common manifestations of bone cancer are bone sarcoma and chondrosarcoma.

Osteogenic sarcoma of the pelvis

This type of malignant tumor forms on the bone tissue in the pelvic area and is the most common in humans. It has been noted that the majority of patients with this disease are children and male adolescents. The tumor grows very quickly, metastases begin to progress in other organs, so it is necessary to notice the development of the disease in time.

Symptoms

Symptoms are pain in the pelvic area, which is not pronounced and therefore does not cause much suspicion, and may be accompanied by an increase in temperature. As the disease progresses, the pain increases, especially when walking.

What are the dangers of osteomyelitis of the hip joint?

As the tumor enlarges, the skin becomes thinner and blood vessels become more visible on it, and a small protrusion appears at the site of the tumor. The pain becomes less and less tolerable, and joint mobility is limited.

The patient begins to feel severe pain at night, which is not relieved by painkillers. Pain is felt when pressing on the affected area.

Chondrogenic sarcoma

This type of tumor forms on cartilaginous tissues and can appear not only on the hip joint, but also spread to the lumbar region and spine. Mostly older men suffer from the disease.

The main symptom is pain, which is present in the symptoms of all types of hip cancer. With chondrosarcoma, pain is mainly localized in the gluteal region, due to the tumor pinching the sciatic nerve, in the thigh. At first it does not cause concern; it may seem that this is a consequence of injury or physical activity, but as the sarcoma grows, the pain increases. Edema and swelling of the thigh are also possible, which is clearly shown in the photo.

The tumor puts pressure on the internal organs, causing a feeling of compression of the internal organs, that is, some kind of internal discomfort.

Manifestations of the disease

Cancer of the pelvic and hip bones is especially dangerous due to its manifestations – metastases. Through the blood, cancer cells quickly spread to neighboring organs, to the brain and lungs, and they are damaged. Symptoms that occur during the formation of metastases:

  1. Bone pain that is not relieved by painkillers.
  2. Pathological fractures - the bone breaks under the slightest load.
  3. Swelling and redness appear in the affected areas.
  4. Critical increase in calcium in the blood.

Other symptoms characteristic of any type of cancer appear:

  • sudden weight loss;
  • sleep disturbance;
  • weakness of the body;
  • decreased appetite.

Often, a patient suffering from bone sarcoma has a low-grade fever for a long time.

Treatment

Treatment for each individual is selected individually, but all methods are divided into surgery, chemotherapy and radiation therapy. Other methods are ineffective. Often, methods in therapy are used in combination.

Surgical method of treatment

Surgery involves removing a malignant tumor. It happens that amputation of a limb may be required when patients present too late. In the past, limb amputation was the main treatment option.

Degrees and types of inflammation of the knee joint and methods of their treatment

Surgery to remove the tumor is most often used. During this procedure, the damaged area is restored using bone grafting from another part of the body. The tissue for transplantation can be taken from a donor. If most of the bone is removed, an implant is placed.

Radiation therapy

Exposure to high-energy X-rays can destroy cancer cells. This method of treatment is not the most effective, but together with chemotherapy it gives positive results even in advanced stages of the disease.

The effect is applied only to the affected area. The intensity is determined by the attending physician; radiation therapy can be used for a long time. It also has an analgesic effect in many cases.

Chemotherapy

With the help of special medications, the process of reproduction of cancer cells is disrupted.

They are extremely toxic, so therapy has contraindications. It is used to curb the progression of the disease, but not all cancer cells can be contained in this way; they either develop resistance to drugs or initially have it.

Osteosarcoma

Osteosarcoma is a malignant neoplasm that affects the human skeletal system and rapidly develops with the formation of multiple metastases. The tumor occurs mainly among young people. Sarcoma originates mainly in the metaphysis - the section of long tubular bones adjacent to the epiphyseal plate. The tendency to early metastasis makes this disease extremely malignant and dangerous.

The majority of patients with osteosarcoma are young men under 25-30 years of age. A surge in the disease is observed during puberty and accelerated skeletal growth. The tubular bones of the lower extremities are affected several times more often than the upper ones. As a rule, the pathological focus covers the femur, humerus or tibia.

Symptoms of cancer of the hip and knee joints

Bones are the basis of the entire body, because without them a person would not exist. A healthy skeleton can withstand loads of up to 1,000 kg.

​out of 5)

​The third stage is accompanied by a pathological fracture of the bone of the affected limb.​

​ In parallel with the main symptoms of cancer, the patient’s sleep is disturbed, daytime activity decreases, appetite is disrupted, and mood and character changes.​

​For example, for breast cancer with secondary bone lesions, chemotherapy or hormonal therapy is initially prescribed if surgery is not possible, after which treatment of metastatic bone lesions begins.​

​Swelling and protrusion on the skin;​

  • ​Similar symptoms occur in many other diseases, but if pain in the limbs lasts more than two weeks, it is recommended to immediately consult a doctor for qualified help and undergo examinations.​
  • ​Primary bone tumors include:​
  • ​X-ray of the joint in 2 standard projections (anterior and lateral).​
  • ​Rapid, in which the process develops within a few months.​

​Symptoms of hand bone cancer​

Alarms

​ Cancer of bones and cartilage tissue of the lower extremities can be of several types: osteoblastoma, Ewing's sarcoma, fibrosarcoma, fibrous histiocytoma, chondroblastoma, sarcoma.​

  1. ​Thus, isolated bone cancer, without metastases, is not the cause of death among such patients. In most cases, patients die from osteogenic tumors when the tumor cells spread throughout the body, giving many distant metastases. In such cases, the mortality rate is 60 percent or more.​
  2. ​With lymphogenous metastasis​
  3. ​The diagnosis is established only by x-ray and after taking a biopsy of the affected area.​

In rare cases, sarcoma of the hip joint occurs. This pathology occurs more often in men than in women.​

Symptoms for various forms of cancer

Bones are the basis of the entire body, because without them a person would not exist. A healthy skeleton can withstand loads of up to 1,000 kg.

  • Relieves pain and swelling in joints due to arthritis and arthrosis
  • Restores joints and tissues, effective for osteochondrosis

To learn more…

Deforming arthrosis is a synonym, another name for osteoarthritis. It is usually used to designate those stages of the disease that are characterized by the presence of characteristic curvatures, osteochondral growths and pathological alignment of the joints. That is, when out of all the variety of clinical manifestations deformations come to the fore.

Signs of bone sarcomas

Diagnosing bone sarcomas at the initial stage of development is extremely difficult. Specialists and patients often mistake dull pain in the joints for inflammatory processes or the consequences of injuries, and are in no hurry to conduct a thorough diagnosis. As the tumor grows, the tissue above it becomes swollen, with a pronounced vascular network.

The joint becomes inactive, contracture develops and a pronounced limitation of physical activity occurs; patients often take a forced position of the body. The tumor itself, when palpated, can be painful and inactive. The local temperature of the pathological focus is often elevated. The pain tends to get worse at night.

Among young patients, the following are common: osteoscarcoma, Ewing's sarcoma, and malignant fibrous histiocytoma. At a more mature age, the following types of bone sarcomas are diagnosed: chondrosarcoma, malignant fibrous histiocytoma, fibrosarcoma. As a rule, such neoplasms metastasize to the lungs, bones and liver.

Methods for diagnosing bone sarcomas:

  • X-ray examination;
  • tumor puncture with morphological examination of tissues;
  • computer, magnetic resonance imaging;
  • positron emission tomography scintigraphy.

Diagnostics

The diagnosis of osteosarcoma is established by an oncologist based on a comparison of the results of histological and radiological examination.

  1. X-ray of the hip.

This examination is carried out to determine the location of the tumor, the presence of pathological fractures, and clarify the size of the tumor.

  1. Histological analysis of cancer tissues.

The essence of a biopsy is to remove a section of pathological tissue for laboratory diagnosis of a cancerous lesion. Studying the structure of the tumor allows us to establish the final diagnosis and stage of oncology.

  1. Osteoscintigraphy.

A method for diagnosing microfoci of pathology using changes in bone saturation with isotopes.

  1. Computed tomography, which determines the exact location of the tumor, its size and the extent of cancer.
  2. Magnetic resonance imaging.

This diagnostic method is considered the most effective way to identify a malignant lesion. Magnetic resonance imaging allows one to evaluate the dynamic progression of the disease and plan a treatment plan.

  1. Angiography is a way to determine the functional state of blood vessels in the affected area.

Therapy methods

The doctor selects treatment individually for each patient. The specialist takes into account the patient’s condition, the characteristics of his body and the course of malignant processes. In most cases, several methods of treating hip cancer are used at once.

Surgery

During the procedure, doctors remove the malignant tumor. Surgery is most often prescribed to patients. If necessary, surgeons amputate the entire leg, but this happens at the last stage of the disease, when the person went to the hospital too late.

During the manipulations, doctors restore the damaged area. A transplant of donor bone tissue or your own from another part of the body is carried out. If the surgeon removes most of the bone during surgery, the patient will receive an implant.

Radiation therapy

During cancer treatment, high-energy X-rays are used, which negatively affect malignant cells, killing them. Therapy is carried out comprehensively. It is impossible to achieve a positive result with rays alone. Doctors prescribe treatment along with chemotherapy.

An integrated approach allows you to fight hip bone tumors even in advanced stages of the disease. During radiation therapy, only the affected area of ​​the body is exposed.

The intensity and duration of treatment is determined by the doctor. Radiation therapy can be used over a long period and also reduces pain.

Treatment with chemotherapy

Patients are prescribed special medications that stop the spread of malignant cells. The doctor selects medications, taking into account the characteristics of the human body and the development of the tumor. You cannot take the medication yourself. The active ingredients kill not only cancer cells, healthy tissues are also at risk.

Chemotherapy has certain contraindications. Drugs help contain malignant processes, but this does not always happen. Some types of tumors develop resistance to drugs or are inherently resistant to drugs.

Treatment methods for hip cancer

Based on the results of the diagnosis, the doctor determines treatment methods and prognosis. Typically, a combination of drug and surgical therapy is used. The following methods are used:

  • drug treatment - a patient with joint cancer is prescribed Vepesid, Ifosfamide and similar drugs. Course duration is 7-10 months. Based on the results, a thorough re-diagnosis of the tumor is carried out to determine the progress achieved.
  • Radiation therapy affects the site of tumor development.
  • Surgical intervention - in case of joint cancer, the tumor is removed completely or partially. If the pathology has reached stages 3-4 of progression, the patient is indicated for bone marrow transplantation. The survival rate in this case is about 30%.

Three typical techniques are used to treat TBD cancer:

  1. Surgery. The changed tissues and some healthy ones are excised along with regional lymph nodes. In the case of an advanced pathological process, the limb is amputated - this allows saving the patient’s life.
  2. Radiation therapy. High activity X-rays are used at an early stage of the disease.
  3. Chemotherapy. This technique is required before radical intervention is performed to reduce the size of a cancer tumor or stop its growth by destroying cancer cells.

A rigid orthosis may be needed after surgery

The outcome of the pathological process depends on the stage of development at which the formation was detected

The type of tumor is also important. If cancer is diagnosed in the early stages and treatment is started promptly, about 80% of all patients survive

If there are metastases, this figure decreases to 50%.

For 5 years after treatment, the patient requires regular clinical examination.

Forecast

The prognosis for recovery of patients with chondrosarcomas is quite favorable. It directly depends on the timeliness of treatment, the degree of malignancy of the tumor and the quality of the operation performed. Treatment of chondrosarcomas requires considerable professionalism from doctors. Therefore, when choosing a clinic, you should give preference to specialized institutions with considerable experience in treating bone tumors and an individual approach to each individual patient.

After successful surgical intervention, more than 25% of patients live for 5 years or more. To prevent recurrence of the pathology, such patients are recommended to undergo regular diagnostics and preventive examinations.

Chondroblastoma tumors

Often a benign soft tissue tumor forms on the thigh.

In particular, young men over the age of 20 are characterized by a benign tumor of cartilage tissue, chondroblastoma. Most often located in the area of ​​the projection of the femoral neck, in the area of ​​the knee or shoulder.

The leading symptoms of chondroblastoma are periodic or constant pain, the appearance of an oval or round swelling. The neoplasm is determined by touch.

To clarify the diagnosis and localization of the affected area, an x-ray examination is indicated. The image will help determine the extent of tumor growth. Clear, even contours are an indirect sign that the tumor is benign. To exclude the presence of calcifications in the tissue, a computed tomogram is performed. Histological examination is considered the most accurate diagnostic method; it will help distinguish chondroblastoma from a malignant tumor or tuberculous process.

Treatment of chondroblastoma is exclusively surgical. The affected area of ​​cartilage and bone is excised, and if necessary, an endoprosthesis is then made.

Chondrosarcoma

Chondrosarcoma is a type of malignant tumor that affects cartilage tissue. The disease is quite common, accounting for up to 10-15% of all bone tumors. It is diagnosed in people of all ages, but more than 60% of patients belong to the mature age group (after 40 years). In 15% of patients with chondrosarcomas, the tumor develops secondarily from osteochondral exostoses, chondromas, and deforming osteosis.

It has been noted that chondrosarcoma most often affects the bones of the pelvis, upper limbs and ribs. Men get sick slightly more often than women. The etiology of the disease is not completely clear. Predisposing factors include gene mutations, the presence of certain hereditary pathologies, and carcinogenic effects on the human body.

Provoking reasons

Doctors cannot say with certainty what factors contribute to the development of malignant processes

There are many reasons that experts recommend patients pay attention to

First of all, it is a hereditary predisposition or mutation that affects the fetus during pregnancy. Provoking factors also include the following reasons:

  1. Old or not fully healed bone injury.
  2. Chemical influence of beryllium or phosphorus.
  3. Recurrence of a malignant tumor.
  4. Human presence in the radioactive zone.
  5. X-ray examination, carried out more than once a year.

Children and adolescents who are addicted to tobacco products are also at risk. A tumor in the hip joint is characterized by rapid progression. Emerging metastases affect nearby tissues.

Signs of chondrosarcoma

Chondrosarcoma is characterized by an asymptomatic gradual course. At the initial stage of development, there are no pathological signs. As the tumor grows, pain begins to occur in the area where the chondrosarcoma is located. If it is located near the joint, then in the clinical picture of the disease there are signs of limited movement.

If the tumor begins to compress the sciatic nerve (if localized in the thigh area), then the pain changes from minor to unbearable. The skin above the tumor becomes swollen; the tumor itself, which has reached a significant size, can be easily palpated. In 15% of patients, fast-growing chondrosarcomas are found, prone to accelerated growth and rapid malignancy.

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